Microglia regulate synaptic development and plasticity.
Microglia regulate synaptic development and plasticity.
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DOI：
10.1002/dneu.22814
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发表时间：
2021-07
影响因子：
3
通讯作者：
Koyama R
中科院分区：
文献类型：
--
作者：
Andoh M;Koyama R
突触是神经回路的基本结构，在神经元之间传递信息。因此，通过适当的突触连接形成神经回路的过程塑造了大脑功能和动物行为的基础。在生物体的整个生命周期中，突触不断地经历反复的形成和消除，这反映了神经回路功能的动态变化。突触的结构转变主要是与神经活动依赖的突触功能增强和减弱相关，即突触的功能可塑性。越来越多的研究揭示了小胶质细胞（一种以高度活动的突起监测脑实质的脑内驻留免疫细胞）在突触形成和消除以及调节突触功能方面的作用。在过去的15年中，小胶质细胞依赖的突触可塑性调节的分子机制已得到深入研究，研究人员报告称，小胶质细胞依赖的调节被破坏会导致突触功能障碍，进而引发脑部疾病。在这篇综述中，我们将广泛介绍有关小胶质细胞在突触可塑性中的作用以及可能的潜在分子机制的研究。
Synapses are fundamental structures of neural circuits that transmit information between neurons. Thus, the process of neural circuit formation via proper synaptic connections shapes the basis of brain functions and animal behavior. Synapses continuously undergo repeated formation and elimination throughout the lifetime of an organism, reflecting the dynamics of neural circuit function. The structural transformation of synapses has been described mainly in relation to neural activity‐dependent strengthening and weakening of synaptic functions, that is, functional plasticity of synapses. An increasing number of studies have unveiled the roles of microglia, brain‐resident immune cells that survey the brain parenchyma with highly motile processes, in synapse formation and elimination as well as in regulating synaptic function. Over the past 15 years, the molecular mechanisms underlying microglia‐dependent regulation of synaptic plasticity have been thoroughly studied, and researchers have reported that the disruption of microglia‐dependent regulation causes synaptic dysfunction that leads to brain diseases. In this review, we will broadly introduce studies that report the roles of microglia in synaptic plasticity and the possible underlying molecular mechanisms.
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耦合的增殖和凋亡维持成人大脑中小胶质细胞的快速离职。
影响因子：
8.8
作者：
Askew K;Li K;Olmos-Alonso A;Garcia-Moreno F;Liang Y;Richardson P;Tipton T;Chapman MA;Riecken K;Beccari S;Sierra A;Molnár Z;Cragg MS;Garaschuk O;Perry VH;Gomez-Nicola D
通讯作者：
Gomez-Nicola D
影响因子：
16.2
作者：
Berry KP;Nedivi E
通讯作者：
Nedivi E
影响因子：
5.3
作者：
Cope, Elise C.;LaMarca, Elizabeth A.;Gould, Elizabeth
通讯作者：
Gould, Elizabeth
影响因子：
32.4
作者：
Filipello, Fabia;Morini, Raffaella;Matteoli, Michela
通讯作者：
Matteoli, Michela
影响因子：
5.3
作者：
Balkowiec, A;Katz, DM
通讯作者：
Katz, DM