Prevalence of HIV, Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal.
Prevalence of HIV, Hepatitis B and C Infections and an Assessment of HCV-Genotypes and Two IL28B SNPs among People Who Inject Drugs in Three Regions of Nepal.
复制标题
DOI：
10.1371/journal.pone.0134455
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Dixit S
中科院分区：
文献类型：
--
作者：
Kinkel HT;Karmacharya D;Shakya J;Manandhar S;Panthi S;Karmacharya P;Sitaula D;Thapaliya R;K C P;Rai A;Dixit S
作为针对尼泊尔吸毒者的综合医疗保健方案的一部分，对尼泊尔三个地区随机抽取的401名注射吸毒者进行了艾滋病毒和病毒性肝炎B和丙型状态（包括风险因素、HCV基因型和合并感染）以及两种IL 28 B单核苷酸多态性（SNP）评估：中西部特莱（尼泊尔根杰）、东部地区（达兰、比拉德纳加尔）和中部地区（加德满都、拉利布尔和奇特旺）。包括至少表现出最低限度的寻求医疗保健行为的个人。后一项标准的定义是在任何提供保健服务的组织注册。调查对象平均年龄30.5岁，平均静脉吸毒时间8.5年，HBsAg、抗-HIV抗体和HCV-RNA阳性率分别为3.5%、13.8%和41.9%。在所有抗HCV抗体检测呈阳性的患者中，16%的患者的HCV自发清除率明显。HCV-RNA阳性的独立危险因素是年龄、性别、地理区域、注射吸毒时间、监禁史和HIV合并感染。在≤24岁的年龄组中，HCV自发清除率为43.5%。总体而言，59.8%的HCV感染是由HCV基因型3引起的，40.2%是由HCV基因型1引起的。本研究未发现其他HCV基因型。在122例患者中确定了IL 28 B SNP rs 12979860和rs 8099917，所有参与者中有75.4%同时具有有利的基因型rs 12979860 C/C和rs 8099917 T/T。
As part of a comprehensive health care programme for people who use drugs in Nepal, HIV and viral hepatitis B and C status—including risk factors, HCV-genotypes and co-infections—as well as two IL28B Single-nucleotide polymorphisms (SNPs) were assessed for a random sample of 401 people who inject drugs in three regions of Nepal: mid-western Terrai (Nepalgunj), the eastern region (Dharan, Biratnagar) and the central region (Kathmandu, Lalitpur and Chitwan). Individuals were included who showed at least a minimum of health care seeking behaviour. This latter criterion was defined by being registered with any organisation offering health services. The average age of the participants was 30.5 yrs, and the average length of intravenous drug use was 8.5 yrs. The prevalence rates of HBsAg, anti-HIV antibodies and HCV-RNA were 3.5%, 13.8% and 41.9%, respectively. Spontaneous HCV clearance was evident in 16% of all of those who tested positive for anti-HCV antibodies. Independent risk factors for HCV-RNA positivity were age, gender, geographical region, duration of injecting drug use, history of imprisonment and HIV co-infection. In the age group ≤24 yrs, the rate of spontaneous HCV clearance was 43.5%. Overall, 59.8% of HCV infections were caused by HCV genotype 3 and 40.2% by HCV genotype 1. No other HCV genotypes were identified in this study. The IL28B SNP rs12979860 and rs8099917 were identified in 122 patients, and 75.4% of all participants had both favourable genotypes rs12979860 C/C and rs8099917 T/T.