C-H bond activation enables the rapid construction and late-stage diversification of functional molecules
C-H bond activation enables the rapid construction and late-stage diversification of functional molecules
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DOI：
10.1038/nchem.1607
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发表时间：
2013-05-01
期刊：
影响因子：
21.8
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Wencel-Delord, Joanna;Glorius, Frank
世纪初，C-H键活化领域取得了重大进展，这种转变现在是合成化学家工具箱中的一个既定部分。这种方法有可能用于许多不同的化学领域，例如，它为各种有机支架的后期多样化提供了一个完美的机会，从相对小的分子如候选药物，到复杂的多分散有机化合物如聚合物。通过这种方式，C-H激活方法可以相对直接地获得过多的类似物，或者可以帮助简化先导物优化阶段。此外，现在可以设计出比以前的方法更节省原子和步骤的复杂有机材料的合成途径，并且在某些情况下，可以基于没有C-H活化就不可能实现的合成断开。该观点强调了金属催化的C-H键活化反应的潜力，该反应现已超出传统合成有机化学领域。
The beginning of the twenty-first century has witnessed significant advances in the field of C-H bond activation, and this transformation is now an established piece in the synthetic chemists' toolbox. This methodology has the potential to be used in many different areas of chemistry, for example it provides a perfect opportunity for the late-stage diversification of various kinds of organic scaffolds, ranging from relatively small molecules like drug candidates, to complex polydisperse organic compounds such as polymers. In this way, C-H activation approaches enable relatively straightforward access to a plethora of analogues or can help to streamline the lead-optimization phase. Furthermore, synthetic pathways for the construction of complex organic materials can now be designed that are more atom-and step-economical than previous methods and, in some cases, can be based on synthetic disconnections that are just not possible without C-H activation. This Perspective highlights the potential of metal-catalysed C-H bond activation reactions, which now extend beyond the field of traditional synthetic organic chemistry.