A Top-Down Cortical Circuit for Accurate Sensory Perception
A Top-Down Cortical Circuit for Accurate Sensory Perception
复制标题
DOI：
10.1016/j.neuron.2015.05.006
复制
发表时间：
2015-06-03
期刊：
影响因子：
16.2
通讯作者：
Murayama, Masanori
中科院分区：
文献类型：
--
作者：
Manita, Satoshi;Suzuki, Takayuki;Murayama, Masanori
感觉信息皮层处理的一个基本问题是，从大脑高级区域到初级感觉区域的自上而下的控制回路是否不仅调节感知，而且积极参与感知。在这里，我们报告的识别神经回路的自上而下的控制在小鼠体感系统。该回路由M2次级运动皮层和S1初级躯体感觉皮层之间的长程相互投射组成。在体内的生理记录显示，感觉刺激诱导顺序S1到M2，然后由M2到S1的神经活动。从M2到S1的自上而下的投射引发了树突棘波和S1层5（L5）神经元的持续放电。M2输入到S1的光遗传抑制降低了L5放电和触觉表面的准确感知。这些发现表明，对感觉区域的重复输入对于准确感知至关重要，并为一种自上而下的控制回路提供了生理模型。
A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. Here, we report the identification of a neural circuit for top-down control in the mouse somatosensory system. The circuit consisted of a long-range reciprocal projection between M2 secondary motor cortex and S1 primary somatosensory cortex. In vivo physiological recordings revealed that sensory stimulation induced sequential S1 to M2 followed by M2 to S1 neural activity. The top-down projection from M2 to S1 initiated dendritic spikes and persistent firing of S1 layer 5 (L5) neurons. Optogenetic inhibition of M2 input to S1 decreased L5 firing and the accurate perception of tactile surfaces. These findings demonstrate that recurrent input to sensory areas is essential for accurate perception and provide a physiological model for one type of top-down control circuit.