Regulation and pro-inflammatory function of interleukin-17 family cytokines.
Regulation and pro-inflammatory function of interleukin-17 family cytokines.
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DOI：
10.1111/j.1600-065x.2008.00709.x
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发表时间：
2008-12
影响因子：
8.7
通讯作者：
Dong C
中科院分区：
文献类型：
--
作者：
Dong C
在哺乳动物中，白介素17(IL-17)家族由六种细胞因子组成。其中，IL-17和IL-17F由一种新的CD4+辅助T细胞亚群表达，在炎症和自身免疫中发挥重要作用。IL-17E，也称为IL-25，与过敏反应有关。在这里，我总结了我的实验室以及其他研究人员最近在理解这三种细胞因子的调节和功能方面所做的工作。从这些研究来看，IL-17家族细胞因子可能成为免疫和炎症性疾病药物干预的新靶点。
The interleukin-17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T cells and play critical function in inflammation and autoimmunity. IL-17E, also called IL-25, has been associated with allergic responses. Here I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.