The prevalence, risk factors and antifungal sensitivity pattern of oral candidiasis in HIV/AIDS patients in Kumba District Hospital, South West Region, Cameroon
The prevalence, risk factors and antifungal sensitivity pattern of oral candidiasis in HIV/AIDS patients in Kumba District Hospital, South West Region, Cameroon
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DOI：
10.11604/pamj.2020.36.23.18202
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发表时间：
2020-05-19
影响因子：
1.2
通讯作者：
Cumber, Samuel Nambile
中科院分区：
文献类型：
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作者：
Ambe, Ngwa Fabrice;Longdoh, Njunda Anna;Cumber, Samuel Nambile
前言：口腔念珠菌病是HIV/AIDS患者最常见的机会性感染之一，由念珠菌引起。低绝对CD 4 + T淋巴细胞计数传统上被认为是口腔念珠菌病发展的最大风险因素。本研究的目的是确定从HIV/AIDS患者口腔中分离的念珠菌属，以确定其体外抗真菌药物敏感性，并调查与口腔念珠菌病相关的可能危险因素。研究方法：这是一项基于医院的横断面研究，在昆巴区医院的HIV/AIDS患者中进行了为期3个月的研究，无论是否接受HAART。用无菌棉拭子采集378例受试者的口腔拭子，并采集静脉血5 ml用于CD 4细胞测定。分离并鉴定念珠菌属。采用改良kirby-bauer药敏试验技术进行抗真菌药敏试验。结果如下：念珠菌属的检出率为42.86%，其中白色念珠菌占60.2%，其次为光滑念珠菌（16.9%）、克柔念珠菌（12.3%）、热带念珠菌（6.4%）、近曲念珠菌（2.3%）和假热带念珠菌（1.8%）。妊娠、口腔卫生和抗生素使用与HIV/AIDS患者口腔念珠菌感染显著相关（P
Introduction: oral candidiasis is one of the most common opportunistic infection in HIV/AIDS patient and it is caused by Candida species. The low absolute CD4+T-lymphocyte count has traditionally been cited as the greatest risk factor for the development of Oral Candidiasis. The aim of this study was to identify Candida species isolated from the oral cavity of HIV/AIDS patients, to determine their in vitro antifungal susceptibility and to investigate the possible risk factors associated with oral candidiasis. Methods: this was a hospital based cross sectional study that was carried out for a period of 3 months amongst HIV/AIDS patients in Kumba District Hospital, whether on HAART or not. Mouth swabs were collected from 378 participants using sterile cotton wool swabs and 5ml venous blood were collected for determination of CD4 cell. Candida species were isolated and identified. Antifungal sensitivity testing was performed using modified kirby-bauer susceptibility testing technique. Results: Candida species were present in 42.86% of the samples and Candida albicans was the most prevalent (60.2%) amongst the six Candida isolates identified, followed by Candida glabrata (16.9%), Candida krusei (12.3%), Candida tropicalls (6.4%), Candida parapsdosis (2.3%) and Candida pseudotropicalls (1.8%). Pregnancy, oral hygiene and antibiotic usage were significantly associated with oral candidiasis in HIV/AIDS patients (P