Highly sensitive and selective acetone sensor based on C-doped WO3 for potential diagnosis of diabetes mellitus
Highly sensitive and selective acetone sensor based on C-doped WO3 for potential diagnosis of diabetes mellitus
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DOI：
10.1016/j.snb.2014.04.015
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发表时间：
2014-08
影响因子：
8.4
通讯作者：
T. Xiao;Xiuyan Wang;Zhao Zhihua;Liu-xia Li;Lin Zhang;H. Yao;Jianshe Wang;Zhongjun Li
中科院分区：
文献类型：
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作者：
T. Xiao;Xiuyan Wang;Zhao Zhihua;Liu-xia Li;Lin Zhang;H. Yao;Jianshe Wang;Zhongjun Li
人体呼气中的丙酮是非侵入性糖尿病临床诊断的重要生物标志物。传统的呼吸分析方法存在一些重大的技术问题和局限性。在这里，C掺杂WO_3材料是通过简单的棉纤维模板法合成的，然后经过焙烧。用X射线衍射仪(XRD)、X射线光电子能谱(XPS)、拉曼光谱和高分辨电子显微镜(HRTEM)对产物的物相和形貌进行了表征。基于C掺杂WO_3材料制成的传感器在300℃的工作温度下对丙酮气体表现出快速的响应和恢复，低至0.2ppm，浓度与检测响应之间有良好的关系，当暴露在甲醇、乙醇和NH3中时，在相同的温度下只有轻微的响应，显示出良好的选择性。此外，即使在95%的相对湿度下，健康人(<；0.9ppm)和糖尿病患者(>；1.8ppm)也可以通过传感器响应的明显差距来区分。结果表明，合成的C掺杂WO_3不仅可以作为一种有效的丙酮检测材料，而且可以为糖尿病的非侵入性诊断提供一种替代体积更大的系统的经济有效的选择。
Acetone in the human breath is a crucial biomarker for the clinical diagnosis of diabetes in a noninvasive manner. Traditional methods of breath analysis have some major technical problems and limitations. Herein, C-doped WO3materials are synthesized via a facile cotton fiber-templating route following by calcination. The phase and morphology of the resulting material were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectra and high resolution transmission electron microscopies (HRTEM). The as-fabricated sensors based on C-doped WO3materials show fast response and recovery toward acetone gas down to 0.2 ppm with a well-defined relationship between the concentration and detection response at an operating temperature of 300 °C. Upon exposure to methanol, ethanol and NH3, only slight responses were observed at the same temperature, indicating an excellent selectivity. Furthermore, healthy persons (<0.9 ppm) and diabetic patients (>1.8 ppm) can be distinguished by an obvious gap in sensor response even at 95% relative humidity. The results suggest that the synthesized C-doped WO3could not only be used as an effective acetone detecting material but offer a cost-effective alternative to more bulky systems for noninvasive diagnosis of diabetes.