Detection of bis(diphenylarsine)oxide, diphenylarsinic acid and phenylarsonic acid, compounds probably derived from chemical warfare agents, in drinking well water
Detection of bis(diphenylarsine)oxide, diphenylarsinic acid and phenylarsonic acid, compounds probably derived from chemical warfare agents, in drinking well water
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DOI：
10.1248/jhs.51.130
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发表时间：
2005-04-01
影响因子：
--
通讯作者：
Hanaoka, S
中科院分区：
文献类型：
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作者：
Ishizaki, M;Yanaoka, T;Hanaoka, S
生活在茨木县神栖镇的木崎地区的特定区域的居民表现出罕见的临床中枢神经系统症状。石墨炉原子吸收分光光度计在他们的饮用井水中检测到明显升高的砷浓度（4.5 ppm）。使用HPLC、GUMS和HPLC/ICP/MS进行的进一步研究表明，砷的结构是双（二苯砷）氧化物（BDPAO）、二苯胂酸（DPAA）和苯胂酸（PAA），这些化合物可以衍生自化学战剂二苯氯砷化氢（DA）和二苯氰砷化氢（DC）。井水中砷化合物的主要形式是DPAA（最大15 ppm），因此计算出居民每天摄入11-30 mg DPAA。这是第一份关于居民因饮用受有机砷化合物污染的井水而受伤的报告，这些化合物可能来自化学武器。
The inhabitants living in a specific region of Kizaki area in Kamisu-town, Ibaraki Prefecture exhibited uncommon clinical central nervous system symptoms. A graphite furnace atomic absorption spectrophotometer detected markedly elevated concentration of arsenic (4.5 ppm) in their drinking well water. Further investigation using HPLC, GUMS and HPLC/ICP/MS demonstrated that the structures of the arsenic were bis(diphenylarsine)oxide (BDPAO), diphenylarsinic acid (DPAA) and phenylarsonic acid (PAA), compounds that can be derived from the chemical warfare agents, diphenylchloroarsine (DA) and diphenylcyanoarsine (DC). The predominant form of the arsenic compound in the well water was DPAA (maximum 15 ppm), so that it was calculated that the inhabitants ingested 11-30 mg of DPAA daily. This is the first report of inhabitants that were injured by drinking well water contaminated with organic arsenic compounds that were likely derived from chemical weapons.