Acyl and Silyl Group Effects in Reactivity-Based One-Pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4
Acyl and Silyl Group Effects in Reactivity-Based One-Pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4
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DOI：
10.1021/ja300284x
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发表时间：
2012-03-14
影响因子：
15
通讯作者：
Wong, Chi-Huey
中科院分区：
文献类型：
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作者：
Hsu, Yun;Lu, Xin-An;Wong, Chi-Huey
相对反应性评估表明，不同位置的硅烷基团可使甲苯基硫代葡萄糖苷具有分级的活性增强作用，但酰基对应物则无此作用。这些发现应用于基于反应性的一锅法组装连接体连接的Lc(4)和IV(2)Fuc - Lc(4)，它们是人类胚胎干细胞表面的组成成分。还对糖 - 半乳糖凝集素 - 1的结合进行了检测。
Relative reactivity evaluations showed the graded arming of toluenyl thioglucosides by variously positioned silyl groups but not by their acyl counterparts. These findings were applied in reactivity-based one-pot assembly of linker-attached Lc(4) and IV(2)Fuc-Lc(4), which are components of human embryonic stem cell surface. The sugar-galectin-1 binding was also examined.