Electrophysiological basis for the ability of olanzapine to improve verbal memory and functional outcome in patients with schizophrenia: A LORETA analysis of P300
Electrophysiological basis for the ability of olanzapine to improve verbal memory and functional outcome in patients with schizophrenia: A LORETA analysis of P300
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DOI：
10.1016/j.schres.2008.01.020
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Kurachi, Masayoshi
中科院分区：
文献类型：
--
作者：
Higuchi, Yuko;Sumiyoshi, Tomiki;Kurachi, Masayoshi
事件相关电位 (ERP) P300 波形的异常被认为代表了精神分裂症病理生理学的一个方面。先前的研究指出，左半球离散大脑区域的神经功能改变导致了精神分裂症的精神病症状和认知缺陷。在这项研究中，我们试图确定：1）精神分裂症患者是否会引起大脑区域（例如颞上回（STG））的 P300 电流源密度降低； 2) 如果通过最广泛使用的抗精神病药物奥氮平治疗，左侧 STG 中降低的 P300 发生器密度得以恢复； 3) P300 源密度的恢复是否与认知和功能状态的改善相关。对 16 名右利手精神分裂症患者在接受奥氮平治疗 6 个月之前和之后评估了对听觉奇怪任务的 P300 反应，以及言语学习记忆、精神病理学和生活质量。 ERP 数据还从 16 名右手年龄和性别匹配的正常志愿者中获得。使用低分辨率电磁断层扫描 (LORETA) 分析来获取 P300 的电流密度图像。与对照组相比，精神分裂症患者左侧多个脑区的 LORETA 值显着较小，尤其是 STG、额中回和中央前回。奥氮平治疗六个月仅在左侧 STG 中显着增加 P300 源密度。治疗期间，阳性症状、阴性症状、言语学习记忆和生活质量也得到改善。左侧 STG 的 LORETA 值的增加与阴性症状的改善（通过阴性症状评估量表测量）和言语学习记忆（通过日本言语学习测试测量）之间存在显着相关性。根据生活质量量表评估，生活质量的改善与额中回 LORETA 值的增加显着相关，并且往往与中央前回的 LORETA 值相关。这项研究的结果表明，通过 ERP 测量的皮质活动的变化是某些抗精神病药物能够改善精神分裂症患者认知和功能结果的原因。 (C) 2008 Elsevier B.V. 保留所有权利。
Abnormality of P300 waveforms of event-related potentials (ERPs) has been suggested to represent an aspect of the pathophysiology of schizophrenia. Previous work points to the contribution of altered neural function in discrete brain regions in the left hemisphere to psychotic symptoms and cognitive deficits of schizophrenia. In this study, we sought to determine: 1) if patients with schizophrenia elicit a decreased P300 current source density in brain areas, such as the superior temporal gyrus (STG); 2) if decreased P300 generator density in the left STG is recovered by treatment with the most widely-used antipsychotic drug olanzapine; and 3) if the recovery of P300 source density is associated with improvements of cognitive and functional status. P300 in response to an auditory oddball task, as well as verbal learning memory, psychopathology, and quality of life were evaluated in 16 right-handed patients with schizophrenia before and after treatment with olanzapine for 6 months. ERP data were also obtained from 16 right-handed age and gender-matched normal volunteers. Low resolution electromagnetic tomography (LORETA) analysis was used to obtain current density images of P300. Patients with schizophrenia showed significantly smaller LORETA values in several brain regions in the left side, particularly STG, middle frontal gyrus, and precentral gyrus, compared with control subjects. Six-month treatment with olanzapine significantly increased P300 source density only in the left STG. Positive symptoms, negative symptoms, verbal learning memory, and quality of life were also improved during treatment. Significant correlations were found between the increase in LORETA values of left STG vs. improvements of negative symptoms, as measured by Scale for the Assessment of the Negative Symptoms, and verbal learning memory, as measured by the Japanese Verbal Learning Test. Improvement of quality of life, as evaluated by the Quality of Life Scale, were significantly associated with an increase in LORETA values of middle frontal gyrus, and tended to correlate with that of precentral gyrus. The results of this study suggest that changes in cortical activity, as measured by ERPs, are responsible for the ability of some antipsychotic drugs to improve cognition and functional outcome in patients with schizophrenia. (C) 2008 Elsevier B.V. All rights reserved.