TROPOMYOSIN BINDING TO F-ACTIN INDUCED BY MYOSIN HEADS
TROPOMYOSIN BINDING TO F-ACTIN INDUCED BY MYOSIN HEADS
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DOI：
10.1126/science.131972
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
EATON, BL
中科院分区：
文献类型：
--
作者：
EATON, BL
原肌球蛋白是许多肌球蛋白收缩系统中与F-肌动蛋白相关的调节蛋白。如果在体外条件下，原肌球蛋白只与F-肌动蛋白轻微结合，那么添加肌球蛋白头可以诱导它们之间的化学计量结合。肌动蛋白和肌球蛋白头部之间的刚性键的形成可能会导致肌动蛋白发生一些变化，稳定原肌球蛋白的适当结合部位。
Tropomyosin is a regulatory protein associated with F-actin in many actomyosin contractile systems. If in vitro conditions are such that tropomyosin binds only slightly to F-actin, then the addition of myosin heads can induce stoichiometric binding between them. Formation of rigor bonds between actin and myosin heads may cause some change in the actin, stabilizing the appropriate binding site for tropomyosin.