Spatial working memory encoding type modulates prefrontal cortical activity
Spatial working memory encoding type modulates prefrontal cortical activity
复制标题
空间工作记忆编码类型调节前额皮质活动
DOI：
10.1097/wnr.0000000000000761
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发表时间：
2017
期刊：
影响因子：
1.7
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Oi;Y.;Kita;Y.;Suzuki;K.;Okumura;Y.;Okuzumi;H.;Shinoda;H.;& Inagaki;M.
空间工作记忆（SWM）涉及同时编码和顺序编码，但它们神经相关性的差异尚不清楚。我们研究了与这些 SWM 编码类型相关的前额皮质活动的差异。我们还研究了影响个体视觉空间能力（VSA）的大脑活动模式。我们在两种不同的条件下（顺序编码和同时编码）执行了 SWM 任务，并使用近红外光谱检查了 39 名健康成年人的血流动力学活动。与同时条件相比，顺序条件下双侧背外侧前额叶皮层的激活更强烈。这表明 SWM 背后的前额叶皮层活动受到编码类型的调节。我们还发现，在同时条件下，与 VSA 较低的个体相比，VSA 高的个体在右背外侧前额叶皮层的激活较弱。这种低激活被认为反映了高能力个体的神经效率。这些发现预计将有助于更好地理解 SWM 的神经基质。
Spatial working memory (SWM) involves both simultaneous and sequential encoding, but the differences in their neural correlates are unclear. We investigated the differences in prefrontal cortex activity related to these SWM encoding types. We also examined the patterns of brain activity influencing individual visuospatial abilities (VSA). We conducted SWM tasks with two different conditions, sequential and simultaneous encoding, and examined hemodynamic activity in 39 healthy adults using near-infrared spectroscopy. The bilateral dorsolateral prefrontal cortex was activated more strongly in the sequential condition compared with the simultaneous condition. This suggests that prefrontal cortex activity underlying SWM is modulated by the type of encoding. We also found that individuals with high VSA showed weaker activation in the right-dorsolateral prefrontal cortex compared with those with lower VSA during the simultaneous condition. This hypoactivation is thought to reflect neural efficiency in the individuals with high ability. These findings are expected to lead to a better understanding of neural substrates for SWM.