Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI
Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI
复制标题
DOI：
10.1002/mrm.20546
复制
发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Dillon, WP
中科院分区：
文献类型：
--
作者：
Zaharchuk, G;Martin, AJ;Dillon, WP
在补充氧气期间获得的液体衰减反转恢复(FLAIR)图像显示脑脊液(CSF)内的高信号，这可能是由顺磁分子氧诱导的T改变引起的。以往的研究表明，脑脊液的纵向松弛速率(R-1=1/T-1)与氧含量呈线性关系，这使得脑脊液氧分压(PcsfO2)的定量成为可能。在本研究中，对8名呼吸室内空气或100%氧气的正常人的侧脑室、第三脑室、皮质沟和基底池中的脑脊液T-1进行了1.5T的测量。使用人工脑脊液进行的体模研究使PcsfO2的绝对定量成为可能。PcsfO2对室内空气的区域性差异从基底池的65+/-27毫米汞柱到第三脑室的130+/-49毫米汞柱。在100%氧气条件下，基底池和皮质沟的PcsfO2分别增加155+/-45和124+/-34 mm Hg，而侧脑室和第三脑室的PcsfO2无明显变化。使用T方法对呼吸室内空气或100%氧气的人进行的PcsfO2测量与侵入性人类和动物研究的结果相当。类似的方法可以用于非侵入性监测许多无细胞、低蛋白质体液中的氧合作用。(C)2005年Wiley-Liss，Inc.
Fluid-attenuated inversion recovery (FLAIR) images obtained during the administration of supplemental oxygen demonstrate a hyperintense signal within the cerebrospinal fluid (CSF) that is likely caused by T, changes induced by paramagnetic molecular oxygen. Previous studies demonstrated a linear relationship between the longitudinal relaxation rate (R-1 = 1/T-1) and oxygen content, which permits quantification of the CSF oxygen partial pressure (PcsfO2). In the current study, CSF T-1 was measured at 1.5 T in the lateral ventricles, third ventricle, cortical sulci, and basilar cisterns of eight normal subjects breathing room air or 100% oxygen. Phantom studies performed with artificial CSF enabled absolute PcsfO2 quantitation. Regional PcsfO2 differences on room air were observed, from 65 +/- 27 mmHg in the basilar cisterns to 130 +/- 49 mmHg in the third ventricle. During 100% oxygen, PcsfO2 increases of 155 +/- 45 and 124 +/- 34 mmHg were measured in the basilar cisterns and cortical sulci, respectively, with no change observed in the lateral or third ventricles. PcsfO2 measurements in humans breathing room air or 100% oxygen using a T, method are comparable to results from invasive human and animal studies. Similar approaches could be applied to noninvasively monitor oxygenation in many acellular, low-protein body fluids. (c) 2005 Wiley-Liss, Inc.