Detection of malignant tumors:: Whole-body PET with fluorine 18 α-methyl tyrosine versus FDG -: Preliminary study
Detection of malignant tumors:: Whole-body PET with fluorine 18 α-methyl tyrosine versus FDG -: Preliminary study
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DOI：
10.1148/radiology.220.1.r01jl1654
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发表时间：
2001-07-01
期刊：
影响因子：
19.7
通讯作者：
Endo, K
中科院分区：
文献类型：
--
作者：
Inoue, T;Koyama, K;Endo, K
目得：比较全身正电子发射断层扫描（PET）与氟78 α-甲基酪氨酸（FMT）和全身PET与2-[氟18]氟-2-脱氧-D-葡萄糖（FDG）的诊断潜力。材料和方法：19例恶性肿瘤患者或疑似恶性肿瘤患者和5名健康志愿者接受全身PET与FMT和FDG。与FDG摄取相比，FMT在脑、心脏、肺、肝和脊柱中的摄取明显较少。在逐病灶基础上，全身FMT PET描绘恶性肿瘤的灵敏度低于全身FDG PET，但差异无统计学意义（74% [35个病灶中的26个] vs 91% [35个病灶中的32个]，P > 0.05）。FMT PET的阳性预测值上级优于FDG PET（87% [30个病灶中的26个] vs 63% [51个病灶中的32个]，P <0.001）。FMT PET在良恶性病变中的摄取差异有显著性（平均值+/- SD，1.64 +/- 0.96 vs 0.79 +/- 0.23; P < .001），但未使用FDG PET（5.02 +/- 3.56 vs 4.02 +/- 2.90，P < .05）。结论：整个-体部FMT PET在临床上可用于诊断恶性肿瘤，并可有效地描述心脏原发性和转移性病变。区域或大脑中。
PURPOSE: To compare the diagnostic potential of whole-body positron emission tomography (PET) with fluorine 78 alpha -methyltyrosine (FMT) with that of whole-body PET with 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG).MATERIALS AND METHODS: Nineteen patients with or suspected of having malignant tumors and five healthy volunteers underwent whole-body PET with FMT and FDG.RESULTS: in comparison with FDG uptake, FMT uptake was significantly less in the brain, heart, lung, liver, and spine. On a lesion-by-lesion basis, the sensitivity of whole-body FMT PET for depicting malignant tumors was inferior to that of whole-body FDG PET, but this difference was not statistically significant (74% [26 of 35 lesions] vs 91% [32 of 35 lesions], P > .05). The positive predictive value of FMT PET was superior to that of FDG PET (87% [26 of 30 lesions] vs 63% [32 of 51 lesions], P < .001). The difference in uptake between benign and malignant lesions was significant with FMT PET (mean +/- SD, 1.64 +/- 0.96 vs 0.79 +/- 0.23; P < .001)but not with FDG PET (5.02 +/- 3.56 vs 4.02 +/- 2.90, P < .05).CONCLUSION: Whole-body FMT PET is clinically useful in the diagnosis of malignant tumors and may be effective in the depiction of primary and metastatic lesions in the cardiac region or in the brain.