Premature ageing of the immune system: the cause of AIDS?
Premature ageing of the immune system: the cause of AIDS?
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DOI：
10.1016/s1471-4906(02)02338-4
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发表时间：
2002-12-01
影响因子：
16.8
通讯作者：
Rowland-Jones, SL
中科院分区：
文献类型：
--
作者：
Appay, V;Rowland-Jones, SL
免疫系统未能控制 HIV-1 感染以及由此导致的免疫缺陷的原因仍不清楚。尽管有强烈的免疫反应，包括强烈的、可能是功能性的、HIV特异性细胞毒性T淋巴细胞反应，HIV-1仍然在宿主体内持续存在。有趣的是，HIV-1 感染者的免疫学特征与未感染 HIV 的老年人的免疫学特征有许多相似之处。我们认为，通过持续的免疫激活过程，HIV-1感染导致适应性免疫系统老化过程加速，导致免疫资源过早耗尽，从而参与免疫缺陷的发生。这一假设可能为 HIV-1 发病机制提供新的线索，并可能表明需要重新考虑当前对抗该病毒的免疫治疗策略。
The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.