Heat shock factors modulate circadian rhythms
Heat shock factors modulate circadian rhythms
复制标题
热休克因素调节昼夜节律
DOI：
10.1007/978-4-431-55852-1_10
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Hirota;T.;Fukada;Y.
温度变化对生理过程有多种影响，包括产生睡眠/觉醒行为的昼夜节律的生物钟、激素释放、新陈代谢等。即使在恒温哺乳动物中，体温也会以昼夜节律方式波动，从而将时间信息传输到周围组织和细胞。体温节律引起转录因子 HSF1 及其靶标（例如 HSP 基因和时钟基因 Per2）的周期性激活，从而调整外周细胞的昼夜节律振荡以实现同步。因此，HSF1 功能的丧失会导致时钟与温度变化的同步性降低。 HSF1 抑制还会减慢时钟振荡速度，并损害在变化的温度下保持振荡速度恒定的机制。在小鸡松果体中，光敏时钟组织、HSF 和 HSP 基因在一天中的特定时间被光脉冲激活，表明 HSF 通路在生物钟的光依赖性同步中发挥作用。总之，HSF 在调节生物钟功能以响应环境变化方面发挥着重要作用。
Temperature changes have a variety of effects on physiological processes including the circadian clock that generates diurnal rhythms of sleep/wake behavior, hormone release, metabolism, and so on. Even in homeothermic mammals, body temperature fluctuates in a circadian manner that transmits the time information to peripheral tissues and cells. The body temperature rhythms cause cyclic activation of the transcription factor HSF1 and its targets such asHSPgenes and a clock genePer2, resulting in adjustment of the circadian oscillation in peripheral cells for synchronization. Loss of function of HSF1 therefore leads to reduced synchronization of the clock against temperature changes. HSF1 inhibition also slows down the speed of the clock oscillation and impairs the mechanism that maintains the oscillation speed constant under varying temperature. In the chick pineal gland, a photosensitive clock tissue, HSF andHSPgenes are activated by light pulse at a specific time of the day, suggesting a role of the HSF pathway in light-dependent synchronization of the circadian clock. Together, HSF has substantial roles in modulating the circadian clock function in response to environmental changes.