Choice, difficulty, and confidence in the brain
Choice, difficulty, and confidence in the brain
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DOI：
10.1016/j.neuroimage.2010.06.073
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发表时间：
2010-11-01
期刊：
影响因子：
5.7
通讯作者：
Deco, Gustavo
中科院分区：
文献类型：
--
作者：
Rolls, Edmund T.;Grabenhorst, Fabian;Deco, Gustavo
为了提供理解决策和决策信心的神经生物学基础，我们描述和分析了一个基于神经元峰值吸引子的决策模型，该模型预测了突触和神经元活动、fMRI BOLD反应和行为选择作为决策难易程度的函数。尖峰网络模型预测了在简单选择和困难选择上更快、更大的神经元反应的概率决策，也就是说，随着选择之间的可判别性δ 1的增加，这些和突触电流反过来预测了随着可判别性的增加，更大的BOLD反应。在两项功能磁共振成像（fMRI）研究中，我们证实了这些预测，表明大脑区域（如内侧前额叶皮层区域10）与愉快刺激之间的选择决策有关，其BOLD激活与嗅觉和温暖愉悦选择的容易程度呈线性相关。这一特征在眼眶额叶皮质区域中没有发现，该区域代表连续的刺激值，但与选择本身无关。这为决策和决策信心，以及大脑中与spike相关的噪声如何影响选择、信心、突触和神经元活动以及fMRI信号提供了统一和基本的方法(C) 2010 Elsevier Inc
To provide a neurobiological basis for understanding decision-making and decision confidence, we describe and analyze a neuronal spiking attractor-based model of decision-making that makes predictions about synaptic and neuronal activity, the fMRI BOLD response, and behavioral choice as a function of the easiness of the decision, and thus decision confidence The spiking network model predicts probabilistic decision-making with faster and larger neuronal responses on easy versus difficult choices, that is as the discriminability Delta I between the choices increases, and these and the synaptic currents in turn predict larger BOLD responses as the discriminability increases. Confidence, which increases with discriminability, thus emerges from the firing rates of the decision-making neurons in the choice attractor network In two fMRI studies, we confirm these predictions by showing that brain areas such as medial prefrontal cortex area 10 implicated in choice decision-making between pleasant stimuli have BOLD activations linearly related to the easiness of both olfactory and warm pleasantness choices Further. this signature is not found in orbitofrontal cortex areas that represent on a continuous scale the value of the stimuli, but are not implicated in the choice itself This provides a unifying and fundamental approach to decision-making and decision confidence, and to how spiking-related noise in the brain affects choice, confidence, synaptic and neuronal activity, and fMRI signals (C) 2010 Elsevier Inc All rights reserved