Asymptomatic microbleeds in moyamoya disease:: T2*-weighted gradient-echo magnetic resonance imaging study
Asymptomatic microbleeds in moyamoya disease:: T2*-weighted gradient-echo magnetic resonance imaging study
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DOI：
10.3171/jns.2005.102.3.0470
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发表时间：
2005-03-01
影响因子：
4.1
通讯作者：
Hashimoto, N
中科院分区：
文献类型：
--
作者：
Kikuta, K;Takagi, Y;Hashimoto, N
目的。本研究的目的是通过使用 3 特斯拉磁共振 (MR) 成像装置来调查烟雾病 (MMD) 患者无症状微出血 (MB) 的发生率。方法。对 1999 年至 2004 年间因 MMD 住院的 63 名患者的数据进行了回顾性检查，以确定无症状 MB 的发生率。使用 3 和 1.5 特斯拉单位获得的梯度回波 T-2* 加权 MR 成像研究可用于 25 名患者。这些患者包括 5 名男性和 20 名女性，年龄从 17 岁到 66 岁不等（平均年龄 41 +/- 14 岁）。 18 名患者被诊断为缺血性 MMD，7 名患者被诊断为出血性 MMD。还使用相同的 3 特斯拉 MR 成像装置对 34 名健康志愿者进行了评估，其中包括 7 名男性和 27 名女性，年龄范围为 18 至 71 岁（平均年龄 33 +/- 12 岁）。使用 3-tesla MR 装置，11 名患者 (44%) 被证实存在无症状 MB；使用 1.5 特斯拉单位在 7 名患者 (28%) 中检测到了这些物质。在健康个体中进行的 3 特斯拉 MR 研究中，在两名患者 (5.8%) 中发现了 MB。根据 3-tesla MR 研究，MMD 患者的 MB 发生率显着高于健康个体。 18 名缺血性 MMD 患者中的 8 名（44%）和 7 名出血性 MMD 患者中的 3 名（43%）显示出无症状 MB。结论。无论疾病类型如何，MMD 患者的微出血都比健康个体更常见。使用 T-2* 加权 3 特斯拉 MR 成像对 MB 进行评估可能有助于 MMD 的治疗。
Object. The aim of this study was to investigate the incidence of asymptomatic microbleeds (MBs) in patients with moyamoya disease (MMD) by using a 3-tesla magnetic resonance (MR) imaging unit.Methods. Data on 63 patients hospitalized with MMD between 1999 and 2004 were retrospectively examined to determine the incidence of asymptomatic MBs. Gradient-echo T-2*-weighted MR imaging studies obtained using 3- and 1.5-tesla units were available in 25 patients. These patients consisted of five men and 20 women, ranging in age from 17 to 66 years (mean age 41 +/- 14 years). Ischemic MMD was diagnosed in 18 patients, and hemorrhagic MMD in seven. The incidence of MBs was also evaluated using the same 3-tesla MR imaging unit in 34 healthy volunteers including seven men and 27 women, ranging in age from 18 to 71 years (mean age 33 +/- 12 years). Using the 3-tesla MR unit, asymptomatic MBs were demonstrated in 11 patients (44%); they were detected in seven patients (28%) by using the 1.5-tesla unit. In the 3-tesla MR studies in healthy individuals, MBs were found in two patients (5.8%). Based on 3-tesla MR studies, the incidence of MBs was significantly higher in patients with MMD compared with that in healthy individuals. Asymptomatic MBs were demonstrated in eight (44%) of 18 patients with ischemic MMD and three (43%) of seven patients with hemorrhagic MMD.Conclusions. Microbleeds are significantly more common in patients with MMD than in healthy individuals regardless of the disease type. The evaluation of MBs with T-2*-weighted 3-tesla MR imaging might contribute to the treatment of MMD.