Nanostructured Polymer Monoliths for Biomedical Delivery Applications
Nanostructured Polymer Monoliths for Biomedical Delivery Applications
复制标题
用于生物医学输送应用的纳米结构聚合物整体料
DOI：
10.1021/acsabm.0c00228
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Hillmyer, Marc A.
中科院分区：
文献类型：
--
作者：
Xie, Yihui;Hillmyer, Marc A.
药物递送系统被设计成控制治疗剂在体内的释放速率和位置，以实现增强的药物功效并减轻不良副作用。特别地，药物释放植入物提供持续和局部释放。我们报道了通过聚合诱导微相分离（PIMS）合成的纳米结构聚合物整料作为潜在的植入式递送装置。作为一个模型系统，自由的聚（环氧乙烷）均聚物被纳入纳米级聚（环氧乙烷）域内包含的交联聚苯乙烯矩阵。这些聚（环氧乙烷）分子从整料的体外释放作为一个功能的聚（环氧乙烷）加载和摩尔质量，以及聚（环氧乙烷）大链转移剂的摩尔质量和重量分数的PIMS过程中使用的形成整料进行了研究。我们还开发了纳米结构的微针，通过结合PIMS和微细加工技术，靶向有效和长期的经皮给药。最后，考虑到聚（丙交酯）在药物递送装置中的突出性，评价了PIMS整料中微相分离的聚（丙交酯）的降解速率，并与散装聚（丙交酯）进行了比较。
Drug delivery systems are designed to control the release rate and location of therapeutic agents in the body to achieve enhanced drug efficacy and to mitigate adverse side effects. In particular, drug-releasing implants provide sustained and localized release. We report nanostructured polymer monoliths synthesized by polymerization-induced microphase separation (PIMS) as potential implantable delivery devices. As a model system, free poly(ethylene oxide) homopolymers were incorporated into the nanoscopic poly(ethylene oxide) domains contained within a cross-linked polystyrene matrix. Thein vitrorelease of these poly(ethylene oxide) molecules from monoliths was investigated as a function of poly(ethylene oxide) loading and molar mass as well as the molar mass and weight fraction of poly(ethylene oxide) macro-chain transfer agent used in the PIMS process for forming the monoliths. We also developed nanostructured microneedles targeting efficient and long-term transdermal drug delivery by combining PIMS and microfabrication techniques. Finally, given the prominence of poly(lactide) in drug delivery devices, the degradation rate of microphase-separated poly(lactide) in PIMS monoliths was evaluated and compared with bulk poly(lactide).