ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory.
ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory.
复制标题
ADRA2B 缺失变异会影响学前压力对长期记忆的时间依赖性影响。
DOI：
10.1016/j.nlm.2017.02.014
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发表时间：
2017
影响因子：
2.7
通讯作者：
Rorabaugh,BoydR
中科院分区：
文献类型：
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作者：
Zoladz,PhillipR;Dailey,AlisonM;Nagle,HannahE;Fiely,MirandaK;Mosley,BrianneE;Brown,CallieM;Duffy,TessaJ;Scharf,AmandaR;Earley,McKennaB;Rorabaugh,BoydR
过去几十年的大量研究表明，某些遗传变异与生活事件相互作用，使人们更容易患上心理疾病。ADRA2B基因的缺失变体与增强的情绪记忆和杏仁核对情绪刺激的反应有关，可能通过增加创伤记忆形成的可能性来增加创伤后应激障碍（PTSD）或相关表型的易感性。因此，我们研究了这种遗传变异是否会预测非临床样本中学习和记忆的压力效应。235个人暴露于社会评价冷加压试验或控制条件下立即或30分钟前学习的一系列单词，不同的情绪效价和唤醒水平。参与者对单词的记忆在学习后立即（回忆）和24小时（回忆和识别）进行测试，并收集唾液样本对参与者进行ADRA2B缺失变体的基因分型。结果表明，在学习前立即给予的压力选择性地增强了缺失携带者的长期回忆。在学习前30分钟给予的压力损害了男性缺失携带者的识别记忆，而增强了女性缺失携带者的识别记忆。这些发现提供了额外的证据支持ADRA 2B缺失变体携带者保留了一个敏感的应激反应系统，这导致了应激对学习和记忆的放大效应。关于这种遗传变异的证据越来越多，暗示它是创伤记忆形成和PTSD相关表型的易感因素。
Extensive work over the past few decades has shown that certain genetic variations interact with life events to confer increased susceptibility for the development of psychological disorders. The deletion variant of theADRA2Bgene, which has been associated with enhanced emotional memory and heightened amygdala responses to emotional stimuli, might confer increased susceptibility for the development of post-traumatic stress disorder (PTSD) or related phenotypes by increasing the likelihood of traumatic memory formation. Thus, we examined whether this genetic variant would predict stress effects on learning and memory in a non-clinical sample. Two hundred and thirty-five individuals were exposed to the socially evaluated cold pressor test or a control condition immediately or 30 min prior to learning a list of words that varied in emotional valence and arousal level. Participants’ memory for the words was tested immediately (recall) and 24 h after learning (recall and recognition), and saliva samples were collected to genotype participants for theADRA2Bdeletion variant. Results showed that stress administered immediately before learning selectively enhanced long-term recall in deletion carriers. Stress administered 30 min before learning impaired recognition memory in male deletion carriers, while enhancing recognition memory in female deletion carriers. These findings provide additional evidence to support the idea thatADRA2Bdeletion variant carriers retain a sensitized stress response system, which results in amplified effects of stress on learning and memory. The accumulating evidence regarding this genetic variant implicates it as a susceptibility factor for traumatic memory formation and PTSD-related phenotypes.