The first report of the Italian Migraine Registry (I-GRAINE)
The first report of the Italian Migraine Registry (I-GRAINE)
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DOI：
10.1007/s10072-022-06214-5
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发表时间：
2022-07-08
影响因子：
3.3
通讯作者：
Bonassi, Stefano
中科院分区：
文献类型：
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作者：
Barbanti, Piero;Egeo, Gabriella;Bonassi, Stefano
意大利偏头痛注册中心(i-graine)是一项多中心(n=38)的前瞻性、观察性、非干预性研究，旨在提供偏头痛的大数据，以确保根据科学和可持续标准进行适当的临床疾病管理。我们按照系统随机的方法连续招募了受发作性或慢性偏头痛影响的患者。通过面对面访谈收集社会人口学特征、生活方式、偏头痛特征、患者旅程和医疗资源使用等信息。2021年12月31日，我们在12个头痛中心招募了231名患者。偏头痛发生率高(9.6+/-6.9天/月)，重度残疾(MIDAS评分：43.0+/-40.8；HIT-6评分：60.4+/-10.6)。只有一小部分患者(38.1%)以前去过头痛中心。与Triptans(76.3%)相比，非特定急性治疗的应答者(43.5-66.7%)和非特定预防应答者(5.4-35%)与抗CGRP单抗(69.2-78.6%)相比，出现了明显的差异。大多数患者在过去三年中接受了一次专科就诊(66.9%)或诊断性调查(77.4%)-主要由我们的国家卫生系统补贴-分别有64.9%和25%的病例不合适。i-Graine登记预计将提供大量且呈指数级增长的临床、生物学和流行病学信息，并将有助于将偏头痛从边缘化的阴影锥体中转移出来，直到目前为止，这种信息经常被降级。
Italian Migraine Registry (I-GRAINE) is a multicenter (n = 38), prospective, observational, non-interventional study aimed at providing big data on migraine to ensure proper clinical disease management, according to scientific, and sustainability criteria. We enrolled consecutive patients affected by episodic or chronic migraine according to the systematic random method. Information on sociodemographic characteristics, lifestyle, migraine features, patient's journey, and healthcare resource use were gathered using face-to-face interviews.On the date of 31 December 2021, we enrolled 231 patients at 12 headache centers. Most of them were women (84.4%), with high migraine frequency (9.6 +/- 6.9 days/month) and severe disability (MIDAS score: 43.0 +/- 40.8; HIT-6 score: 60.4 +/- 10.6). Only a minority of patients (38.1%) had previously visited a headache center.A clear-cut difference emerged in the proportion of responders to nonspecific acute treatments (43.5-66.7%) compared to triptans (76.3%) and in responders to unspecific prophylaxis (5.4-35%) compared to anti-CGRP monoclonal antibodies (69.2-78.6%). Most patients underwent >= 1 specialist visit (66.9%) or diagnostic investigation (77.4%) over the last 3 years-mostly subsidized by our national health system-inappropriate in 64.9% and 25% of the cases, respectively.The I-GRAINE registry is expected to provide a large and exponentially increasing collection of clinical, biological, and epidemiologic information and will contribute to moving migraine out of the shadow cone of marginalization, which has been often relegated up to now.