REDUCTION IN VIRULENCE OF BABESIA-BOVIS DUE TO RAPID PASSAGE IN SPLENECTOMIZED CATTLE
REDUCTION IN VIRULENCE OF BABESIA-BOVIS DUE TO RAPID PASSAGE IN SPLENECTOMIZED CATTLE
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DOI：
10.1016/0020-7519(79)90083-3
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发表时间：
1979-01-01
影响因子：
4
通讯作者：
MCGREGOR, W
中科院分区：
文献类型：
--
作者：
CALLOW, LL;MELLORS, LT;MCGREGOR, W
在脾脏切除的小牛体内，观察到牛双球菌对正常牛（牛牛双球菌）的毒力明显丧失。在密切研究的2个菌株中，接种了第11代寄生虫的牛对感染的反应很小，尽管脾切除的供体受到严重影响。在完整的宿主中传代后，这种变化被逆转了，在一个实验中，寄生虫在传代第5代时变得非常毒。这一发现有助于研制安全的巴贝斯虫病活疫苗。要么选择免疫原性抗原，要么选择免疫抑制抗原，要么选择这些作用的组合，都可能导致毒力下降。
A marked loss of virulence of B. bovis for normal cattle (B. taurus) was observed during its rapid serial, blood passage in splenectomized calves. In 2 strains studied closely, responses to infection in cattle inoculated with parasites collected from the 11th passages were minimal, although the splenectomized donors were severely affected. The change was reversed by passaging in intact hosts, and in one experiment the parasites had become very virulent at passage 5. The finding was useful in the preparation of safe, living vaccines to control babesiosis. Selection either for immunogenic antigens, against immunosuppressive ones, or a combination of these effects may have caused the decreased virulence.