Left Renal Nerves Stimulation Facilitates Ischemia-Induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion
Left Renal Nerves Stimulation Facilitates Ischemia-Induced Ventricular Arrhythmia by Increasing Nerve Activity of Left Stellate Ganglion
复制标题
左肾神经刺激通过增加左星状神经节的神经活动促进缺血诱发的室性心律失常
DOI：
10.1111/jce.12498
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发表时间：
2014-11-01
影响因子：
2.7
通讯作者：
Jiang, Hong
中科院分区：
文献类型：
--
作者：
Huang, Bing;Yu, Lilei;Jiang, Hong
肾交感神经（RSN）的活动在全身交感神经功能亢进中起着关键作用。以往的研究表明，心脏交感神经，特别是左星状神经节（LSG）的过度兴奋参与了急性心肌梗死（AMI）后室性心律失常（VA）的发病机制。包括LRS（组1，n = 9）、假RSN刺激（组2，n = 9）或LSG消融加3小时LRS（组3，n = 10）。结扎冠状动脉左前降支近端建立急性心肌梗死模型。采用电刺激左肾动脉外膜，使收缩压（BP）升高10%的电压进行LRS。在基线和LRS每小时结束时测量血压、心率变异性（HRV）、血清去甲肾上腺素（NE）水平和LSG功能。第1组和第2组检测LSG中C-fos和神经生长因子（NGF）蛋白的表达。与基线相比，LRS 3小时可导致血压、心率变异性交感神经指数、血清NE水平和LSG功能明显升高。第1组VA的发生率显著高于其他组。结论LRS 3 h可引起全身和心脏交感神经兴奋，并增加缺血性VA的发生率。
Renal Sympathetic Nerves and Ventricular ArrhythmiasIntroductionRenal sympathetic nerve (RSN) activity plays a key role in systemic sympathetic hyperactivity. Previous studies have shown that cardiac sympathetic hyperactivity, especially the left stellate ganglion (LSG), contributes to the pathogenesis of ventricular arrhythmias (VAs) after acute myocardial infarction (AMI).Methods and ResultsTwenty-eight dogs received 3 hours of continuous left-sided electrical stimulation of RSN (LRS; Group-1, n = 9), sham RSN stimulation (Group-2, n = 9), or LSG ablation plus 3 hours of LRS (Group-3, n = 10) were included. AMI was induced by ligating the proximal left anterior descending coronary artery. LRS was performed using electrical stimulation on the adventitia of left renal artery at the voltage increasing the systolic blood pressure (BP) by 10%. BP, heart rate variability (HRV), serum norepinephrine (NE) level, and LSG function were measured at baseline and the end of each hour of LRS. C-fos and nerve growth factor (NGF) protein expressed in the LSG were examined in Group-1 and Group-2. Compared with baseline, 3 hours of LRS induced a significant increase in BP, sympathetic indices of HRV, serum NE level, and LSG function. The incidence of VAs in Group-1 was significantly higher than other groups. The expression of c-fos and NGF protein in the LSG was significantly higher in Group-1 than Group-2.ConclusionThree hours of LRS induces both systemic and cardiac sympathetic hyperactivity and increases the incidence of ischemia-induced VAs.