Kinetics of emitted mass-A study with three dry powder inhaler devices
Kinetics of emitted mass-A study with three dry powder inhaler devices
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DOI：
10.1016/j.ces.2011.07.029
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发表时间：
2011-11-01
影响因子：
4.7
通讯作者：
Stewart, Peter
中科院分区：
文献类型：
--
作者：
Behara, Srinivas Ravindra Babu;Kippax, Paul;Stewart, Peter
本研究的目的是了解三种干粉吸入器装置（Rotahaler（R）（RH）、Monodose Inhaler（R）（MI）和Handihaler（R）（HH））在不同空气流速（30-180 L mm（-1））下微粒化硫酸沙丁胺醇（SS）和lactohale 300（LH 300）的排空动力学。通过实时激光衍射粒度测定确定的气溶胶浓度与时间曲线表明，RH中的大部分粉末在1秒内喷出，而MI和HH中观察到更长时间的气溶胶化。对于SS和LH 300，与MI相比，从RH更快地达到峰值气溶胶浓度。计算的累积排放质量（CCEM）与时间的关系曲线是从气溶胶浓度与时间的关系曲线获得的，排放质量和CCEM的速率（k（CCEM）），从建模方法估计，随着空气流速的增加而增加。SS和LH 300的k（CCEM）与空气流速曲线在高空气流速下显著不同。K（CCEM）以RH最高，MI最低。器械之间的k（CCEM）差异与胶囊孔径大小有关，而材料之间的差异是由于粉末床结构所致。这种方法提供了一种理解的速度，粉末质量从干粉吸入器装置排空，并提出了一个强大的开发工具，为未来的粉末吸入器。(C)2011爱思唯尔有限公司版权所有。
The purpose of this study was to understand the kinetics of emptying of micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30-180 L mm(-1)) from three dry powder inhaler devices, Rotahaler (R) (RH), Monodose Inhaler (R) (MI) and Handihaler (R) (HH). Aerosol concentration vs. time profiles, determined through real-time laser diffraction particle sizing, demonstrated that the majority of the powder from RH was emitted within one second while a more prolonged aerosolisation was observed from MI and HH. Peak aerosol concentrations were achieved more rapidly from RH compared to MI for both SS and LH300. Calculated cumulative emitted mass (CCEM) vs. time profiles were obtained from the aerosol concentration vs. time profiles and the emitted mass and the rate of CCEM (k(CCEM)), estimated from a modelling approach, increased with increasing air flow rates. The k(CCEM) vs. air flow rate profiles of SS and LH300 were significantly different at high air flow rates. The k(CCEM) was highest from RH and lowest from MI. Differences in k(CCEM) between the devices were related to capsule aperture size while the differences between the materials were due to the powder bed structure. This approach provided an understanding of the rate at which powder mass emptied from dry powder inhaler devices and was proposed to be a powerful development tool for the future powder inhalers. (C) 2011 Elsevier Ltd. All rights reserved.