Accurate determination of blood brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients
Accurate determination of blood brain barrier permeability using dynamic contrast-enhanced T1-weighted MRI: a simulation and in vivo study on healthy subjects and multiple sclerosis patients
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DOI：
10.1038/jcbfm.2014.126
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发表时间：
2014-10-01
影响因子：
6.3
通讯作者：
Larsson, Henrik B. W.
中科院分区：
文献类型：
--
作者：
Cramer, Stig P.;Larsson, Henrik B. W.
动态对比增强磁共振成像（DCE-MRI）越来越多地用于估计血脑屏障（BBB）渗漏情况下的渗透率。然而，该方法区分这种低值和零值的能力是未知的，并且在不同生理环境下总测量持续时间、时间分辨率和建模方法的最佳选择上没有达成共识。为了估计DCE-MRI方法的准确性和精度，我们使用双室模型生成模拟数据，并逐步降低采样和截断数据以模拟低时间分辨率和短总测量持续时间。模型拟合与Patlak，扩展阁楼和Tikhonov两室（Tik-2CM）模型进行。总共扫描了17名健康对照以获得体内数据。长总测量时间（15分钟）和高时间分辨率（1.25秒）大大提高了所有三种模型的准确度和精度，使我们能够区分低至0.1 ml/100 g/min的渗透率值。Patlak模型的渗透率值具有最高的准确度和精度
Dynamic contrast-enhanced magnetic resonance imaging-(DCE-MRI) is increasingly used to estimate permeability in situations with subtle blood-brain barrier (BBB) leakage. However, the method's ability to differentiate such low values from zero is unknown, and no consensus exists on optimal selection of total measurement duration, temporal resolution, and modeling approach under varying physiologic circumstances. To estimate accuracy and precision of the DCE-MRI method we generated simulated data using a two-compartment model and progressively down-sampled and truncated the data to mimic low temporal resolution and short total measurement duration. Model fit was performed with the Patlak, the extended lofts, and the Tikhonov two-compartment (Tik-2CM) models. Overall, 17 healthy controls were scanned to obtain in vivo data. Long total measurement duration (15 minutes) and high temporal resolution (1.25 seconds) greatly improved accuracy and precision for all three models, enabling us to differentiate values of permeability as low as 0.1 ml/100 g/min from zero. The Patlak model yielded highest accuracy and precision for permeability values