RELATIONSHIP BETWEEN LIVER SIZE AND BODY SIZE
RELATIONSHIP BETWEEN LIVER SIZE AND BODY SIZE
复制标题
DOI：
10.1148/91.6.1195
复制
发表时间：
1968-01-01
期刊：
影响因子：
19.7
通讯作者：
NORTH, WA
中科院分区：
文献类型：
--
作者：
DELAND, FH;NORTH, WA
随着放射性核素扫描等新的器官可视化技术的出现，了解器官大小相对于身体大小的正常范围是有帮助的。不幸的是，关于这个主题的信息很少。例如，大多数参考文献给出了成年男性或女性的肝脏重量范围，而没有给出与身高或体重的关系(1-5)。在一系列尸检中，Stowens将儿童的肝脏重量与身高联系起来(6)。然而，关于成年人肝脏重量和大小与体重、身高和/或体表的关系的唯一数据是Frericks对24个人进行的研究。因此，我们从约翰·霍普金斯医院病理科的5000份尸检报告中选择了550例，以及从马里兰州法医办公室的档案中挑选了75例非住院尸检病例(男性60例，女性15例)。材料和方法根据以下标准选择550例患者：(A)没有肝脏病理的临床、实验室或尸检证据；(B)没有心血管疾病的证据，如心脏失代偿或外周静脉压升高；(C)没有肝脏系统性疾病的证据，如感染、淋巴瘤、白血病或胶原病。此类病例仅限于那些死于枪伤、严重挤压伤、从高处坠落或车祸的人。如果死亡前有大量出血的证据，则不包括病例。年龄、性别、体重和身高以及肝脏重量的数据被列在表格中。仅在医院系列中，在尸检时测量了肝脏的宽度、高度和深度。根据DuBois和DuBois公式计算体表面积(11)：结果肝脏重量与体重的关系：受试者的体重以5公斤为单位分组。平均肝脏重量(±1S.D.)如图1所示。可以看到，随着体重的增加，肝脏重量增加，但速度较慢。根据Stahl(8)的说法，如果将体重和器官重量之间的指数函数联系起来，动物的体重和器官重量之间的关系更具线性。因此，体重的对数被绘制为横坐标，平均肝脏重量的对数被绘制为纵坐标(图2)。对于体重在3到20公斤之间的人，这种关系几乎是一条直线，斜率约为45°。从体重20-30公斤，肝脏重量的增加率下降，但几乎保持线性。据报道，肝脏在出生时是体重的3.8%(9)。
WITH THE ADVENTof newer technics for organ visualization such as radionuclide scanning, it is helpful to know the normal range of organ size relative to body size. Unfortunately, little information on this subject is available. For example, most references give the range of liver weight in the adult male or female without giving the relationship to body height or weight (1–5). In a series of autopsies, Stowens related liver weight to body height for children (6). The only data, however, on the relationship of liver weight and size to body weight, height, and/or surface in adults are the studies made by Frericks (7) of 24 persons. We selected, therefore, a series of 550 cases from 5,000 autopsy protocols of the Department of Pathology of The Johns Hopkins Hospital, plus 75 nonhospitalized autopsied cases (60 males and 15 females) from the files of the Medical Examiner's Office of the State of Maryland. From these cases studied, we were able to relate liver size to body size.Materials and MethodsThe 550 cases were selected on the basis of the following criteria: (a) no clinical, laboratory, or autopsy evidence of hepatic pathology; (b) no evidence of cardiovascular disease, such as cardiac decompensation or increased peripheral venous pressure ; (c) no evidence of systemic disease of the liver, such as infection, lymphoma, leukemia, or collagen disease.These same criteria were used in the selection of the cases of the Medical Examiner. Such cases were limited to those persons dying instantaneously from gunshot wounds, severe crushing injuries, falls from high structures, or automobile accidents. Cases were not included if there was evidence of significant hemorrhage prior to death.Data on age, sex, body weight and height, and liver weight were tabulated. Measurements of the width, height, and depth of the liver were made at the time of autopsy in only the hospital series. Body surface area was determined from a nomogram based on the formula of DuBois and DuBois(11):ResultsRelationship Between Liver Weight and Body Weight: The body weights of the subjects were grouped in 5 kg increments. The mean liver weight (±1 S.D.) for each increment is shown in Figure 1. It can be seen that as body weight increases, the liver weight increases, but at a slower rate. According to Stahl (8), the relationship between body weight and organ weight in animals is more linear if one relates the exponential function of each. Therefore, the logarithm of body weight was plotted as the abscissa, and the logarithm of the mean liver weight as the ordinate (Fig. 2). For a body weight between 3 and 20 kg the relationship was a nearly straight line with a slope of about 45 °. From 20–30 kg of body weight the rate of increase in liver weight decreased but remained nearly linear. The liver is reported to be 3.8 per cent of body weight at birth (9).