Significance of the Glasgow prognostic score for short-term surgical outcomes: A nationwide survey using the Japanese National Clinical Database.
Significance of the Glasgow prognostic score for short-term surgical outcomes: A nationwide survey using the Japanese National Clinical Database.
复制标题
格拉斯哥预后评分对短期手术结果的意义：使用日本国家临床数据库进行的一项全国性调查。
DOI：
10.1002/ags3.12456
复制
发表时间：
2021-09
影响因子：
2.7
通讯作者：
Takeuchi H
中科院分区：
文献类型：
--
作者：
Hiramatsu Y;Kumamaru H;Kikuchi H;Usune S;Kamiya K;Miyata H;Konno H;Kakeji Y;Kitagawa Y;Takeuchi H
术前基于炎症的格拉斯哥预后评分（GPS）是预测癌症患者长期预后的有用工具。然而，其与术后短期结局的相关性仍然未知。本研究的目的是调查GPS与各种胃肠道恶性肿瘤手术患者术后发病率和死亡率之间的关系。使用日本国家临床数据库，我们分析了2015年1月至2018年12月期间接受6种典型择期手术（包括食管切除术、远端胃切除术、全胃切除术、右半结肠切除术、低位前切除术和胰腺切除术）的312357例胃肠道恶性肿瘤患者的记录。我们将GPS分为0、1或2，分别分配给无白蛋白降低和C反应蛋白水平升高、有一种白蛋白降低和C反应蛋白水平升高或两者均降低的患者。我们研究了GPS与每种手术的手术发病率和死亡率的关系，并对患者的人口统计学、术前状态、合并症和癌症分期进行了调整。在除胰腺切除术外的所有手术中，GPS 1和2的粗手术发病率显著高于GPS 0患者。在所有手术中，GPS 1和GPS 2患者的术后住院时间显著延长（P < .001）。在所有手术中，GPS 1和2患者的手术死亡率也较高。在调整年龄、性别、身体状况、肿瘤分类、术前治疗和合并症等潜在混杂因素后，相关性仍然显著。这项全国性的研究为GPS和术后结局之间的强相关性提供了坚实的证据。本研究旨在探讨格拉斯哥预后评分（GPS）对癌症患者手术发病率和死亡率的意义。我们分析了日本国家临床数据库的记录。这项研究提供了坚实的证据，以加强GPS与手术发病率和死亡率的显着关联。
Preoperative inflammation‐based Glasgow prognostic score (GPS) is a useful tool for predicting long‐term prognosis in cancer patients. However, its association with postoperative short‐term outcomes remains unknown. The aim of this study is to investigate the association between GPS and postoperative morbidity and mortality among patients undergoing surgery for various gastrointestinal malignancies. Using the Japanese National Clinical Database, we analyzed the records of 312 357 patients with gastrointestinal malignancy who underwent six typical elective surgeries, including esophagectomy, distal gastrectomy, total gastrectomy, right hemicolectomy, low anterior resection, and pancreaticoduodenectomy, between January 2015 and December 2018. We assigned GPS of 0, 1, or 2 to patients with no, one, or both decreased albumin and elevated C‐reactive protein levels, respectively. We investigated the relationship of GPS with operative morbidity and mortality for each procedure with adjustments for patients' demographics, preoperative status, comorbidities, and cancer stages. Crude operative morbidity was significantly higher for GPS 1 and 2 than GPS 0 patients in all procedures except pancreaticoduodenectomy. The postoperative length of hospital stay was significantly longer for GPS 1 and 2 patients in all procedures (P < .001). Operative mortality was also higher for GPS 1 and 2 patients in all procedures. The associations remained significant after adjustments for potential confounders of age, sex, physical status, tumor classification, use of preoperative therapy, and comorbidities. This nationwide study provides solid evidence on the strong association between GPS and postoperative outcomes. This study aimed to investigate the significance of Glasgow prognostic score (GPS) for operative morbidity and mortality in cancer patients. We analyzed records from the Japanese National Clinical Database. This study provides solid evidence to reinforce the significant association of GPS with operative morbidity and mortality.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4.3
作者：
Inaoka K;Kanda M;Uda H;Tanaka Y;Tanaka C;Kobayashi D;Takami H;Iwata N;Hayashi M;Niwa Y;Yamada S;Fujii T;Sugimoto H;Murotani K;Fujiwara M;Kodera Y
通讯作者：
Kodera Y
影响因子：
9
作者：
Ishizuka, Mitsuru;Nagata, Hitoshi;Kubota, Keiichi
通讯作者：
Kubota, Keiichi
影响因子：
9
作者：
Kimura, Wataru;Miyata, Hiroaki;Mori, Masaki
通讯作者：
Mori, Masaki
影响因子：
3.2
作者：
Kubota, Takeshi;Hiki, Naoki;Yamaguchi, Toshiharu
通讯作者：
Yamaguchi, Toshiharu