Miniature and Fieldable Mass Spectrometers: Recent Advances.
Miniature and Fieldable Mass Spectrometers: Recent Advances.
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DOI：
10.1021/acs.analchem.5b03070
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发表时间：
2016-01-05
影响因子：
7.4
通讯作者：
Cooks RG
中科院分区：
文献类型：
--
作者：
Snyder DT;Pulliam CJ;Ouyang Z;Cooks RG
我们从单个组件和系统级别来讨论迷你MS系统。重点是学术和商业实验室的便携式系统，但也包括中间系统(小到可以现场使用，但太大而不能手持)和空间系统。讨论模拟是因为它们在设计质量分析器和离子光学中变得越来越重要，并且由于微型质谱仪正在成为在实验室外进行测量的有用工具，因此也讨论了实际应用。小型质谱计最重要的要求是具有足够的性能。分辨率应足以(通常为单位)将分析物离子与其他组分分离，并且灵敏度和选择性应适合预期的测量。该仪器通常适用范围广，但可根据具体应用进行调整(例如，农药测定、爆炸物或毒品检测、反应监测等)。高灵敏度和高特异度是预期的特征，导致对特定分析物的检测和定量限度较低。为了便于携带，电子产品应坚固耐用、价格低廉，并设计为最大限度地减少功耗，使其能够使用电池供电。为了利用可携带性，大多数样品应在不净化的情况下就地电离，而不考虑组成、物相或复杂性。4、5通过在小型MS系统中结合环境电离和串联质谱学来最好地实现这些目标。
We discuss mini MS systems in terms of individual components and at a systems level. Portable systems from academic and commercial laboratories are emphasized, but meso systems (small enough to be fieldable but too large to be hand-portable) and space systems are also included. Simulations are discussed since they have become increasingly important in designing both mass analyzers and ion optics and, because miniature mass spectrometers are emerging as a useful tool for making measurements outside of the laboratory, practical applications are also addressed. The most important requirement for a miniature mass spectrometer is that it have adequate performance. The resolution should be sufficient (usually unit) to separate analyte ions from other components, and the sensitivity and selectivity ought to be appropriate for the intended measurement. The instrument will typically be widely applicable but tunable to a specific application (eg, pesticide determination, explosives or narcotics detection, reaction monitoring, etc.). High sensitivity and specificity are expected characteristics, leading to low detection and quantitation limits for particular analytes. In order to be portable, the electronics should be rugged, inexpensive, and designed to minimize power consumption, enabling operation from battery power. To take advantage of portability, most samples should be ionized without purification, on-site, regardless of composition, phase, or complexity. 4, 5 These objectives are best accomplished through the combination of ambient ionization and tandem mass spectrometry in a small MS system.