Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.
Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.
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发表时间：
1995-01
期刊：
影响因子：
3.3
通讯作者：
M. Georges;Dablia Nielsen;Margaret Mackinnon;A. Mishra;Okimoto;-T.;L. Sargeant;Sorensen;Michael R. Steele;Zhao;James E. Womack;Ina Hoeschele
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作者：
M. Georges;Dablia Nielsen;Margaret Mackinnon;A. Mishra;Okimoto;-T.;L. Sargeant;Sorensen;Michael R. Steele;Zhao;James E. Womack;Ina Hoeschele
我们已经利用“后代检测”来定位选定的奶牛群体中产奶量遗传变异的数量性状基因座（QTL）。共对1,518头公牛进行了159个常染色体微卫星基因分型，其中包括1645 centimorgan或约三分之二的牛基因组。使用最大似然多位点连锁分析来解释表型的方差异质性，我们鉴定了5条染色体，这5条染色体为控制产奶量的QTL的存在提供了非常强的证据（LOD得分>或= 3）：染色体1、6、9、10和20。这些发现表明，对产奶量有相当大影响的基因座在高度选择的群体中仍然分离，并为奶牛育种中的标记辅助选择铺平了道路。
We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding.