Functions and characteristics of PINK1 and Parkin in cancer
Functions and characteristics of PINK1 and Parkin in cancer
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DOI：
10.2741/4321
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Kitagishi, Yasuko
中科院分区：
文献类型：
--
作者：
Matsuda, Satoru;Nakanishi, Atsuko;Kitagishi, Yasuko
大多数帕金森病（PD）相关基因也与癌症有关。特别是，磷酸酶和张力蛋白同源物诱导的激酶1（PINK1）和帕金，这两者都参与了与线粒体功能障碍相关的帕金森病的遗传性家族形式，似乎在癌症中异常表达。功能研究表明，PINK1将Parkin招募到线粒体中以启动线粒体自噬，这是一种重要的自噬质量控制机制，可以清除受损的线粒体。虽然PD和癌症是明显不同的人类疾病，但有证据表明PD患者的癌症发病率较低。癌症发病率和PD之间的关系可能与这两种疾病的共同途径有关。本文简要介绍了PINK1和Parkin的细胞功能。
Most of the Parkinson disease (PD) linked genes are also associated with cancers. In particular, phosphatase and tensin homologue-induced kinase 1 (PINK1) and Parkin, both of which are involved in recessively inherited familial forms of PD linked to mitochondrial dysfunction, appear to be abnormally expressed in cancers. Functional studies have revealed that PINK1 recruits Parkin to mitochondria to initiate mitophagy, an important autophagic quality control mechanism that rids the cell of damaged mitochondria. Although PD and cancer are obviously disparate human disorders, there is an evidence for low cancer rates in patients with PD. The relationship between cancer rates and PD might be related to the involvement of common pathways in both diseases. This paper provides a concise overview on the cellular functions of the PINK1 and Parkin.