Early Results of Neurodevelopment Following Hybrid Stage I for Hypoplastic Left Heart Syndrome
Early Results of Neurodevelopment Following Hybrid Stage I for Hypoplastic Left Heart Syndrome
复制标题
DOI：
10.1007/s00246-014-1065-5
复制
发表时间：
2015-03-01
影响因子：
1.6
通讯作者：
Steward, Deborah
中科院分区：
文献类型：
--
作者：
Cheatham, Sharon L.;Carey, Helen;Steward, Deborah
接受混合 I 期姑息治疗的左心发育不全综合征 (HLHS) 婴儿的运动技能和神经发育尚不清楚。本研究的目的是评估 HLHS 婴儿在混合 I 期姑息治疗后的早期神经发育。 HLHS 婴儿在 2 个月和 4 个月大时使用婴儿运动表现测试进行了混合阶段 I 姑息治疗，并在 6 个月大时在接受第二阶段手术之前使用婴儿和幼儿发育贝利量表第三版 (Bayley-III) 进行了发育评估。将结果与健康对照受试者和常模参考数据进行比较。 HLHS 组在 2 个月大时的 TIMP 得分低于平均值 (p = 0.002)，得分在 -1 到 -2 个标准差 (SD) 之间，在 4 个月大时 (p = 0.0019)，得分在平均值的 -1 SD 以内。与对照组相比，HLHS 组 6 个月大时使用 Bayley-III 的综合运动技能显着较低 (p = 0.0489)，但认知 (p = 0.29) 或语言 (p = 0.68) 方面不显着。 HLHS 组的百分位运动评分为 17 +/- A 20 %，而健康年龄匹配对照组的百分位等级运动评分为 85 +/- A 12 %。与健康年龄匹配的对照组和常模参考人群相比，接受混合 I 期姑息治疗的 HLHS 婴儿在标准化运动技能测试中得分较低。这表明 HLHS 婴儿的运动技能表现比 6 个月大时正常发育的婴儿较差。
Motor skills and neurodevelopment in infants with hypoplastic left heart syndrome (HLHS) who have undergone Hybrid Stage I palliation is unknown. The purpose of this study is to assess early neurodevelopment in infants with HLHS after Hybrid Stage I palliation. Developmental assessment was performed in HLHS infants who underwent Hybrid Stage I palliation at 2 and 4 months of age using the Test of Infant Motor Performance, and at 6 months of age, prior to undergoing the second staged surgery, using the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III). Results were compared to healthy control subjects and norm-referenced data. The HLHS group scored between -1 and -2 standard deviations (SD) below the mean at 2 months of age (p = 0.002), and within -1 SD of the mean, at 4 months of age (p = 0.0019), on the TIMP. Compared to the control group, composite motor skills were significantly lower at 6 months of age on the Bayley-III in the HLHS group (p = 0.0489), however, not significant for cognitive (p = 0.29) or language (p = 0.68). Percentile rank motor scores were 17 +/- A 20 % in the HLHS group compared to 85 +/- A 12 % for the healthy age-matched control group. Infants with HLHS who undergo Hybrid Stage I palliation score lower on standardized motor skill tests compared to healthy age-matched controls and the norm-referenced population. This suggests that infants with HLHS have poorer motor skill performance than typically developing infants at 6 months of age.