New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm.
New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm.
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DOI：
10.1117/1.jbo.17.6.068003
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发表时间：
2012-06
影响因子：
3.5
通讯作者：
Ying Wang;Zhaohui Zuo;Y. Gu;N. Huang;Rong Chen;Buhong Li;H. Qiu;J. Zeng;Jianguo Zhu;
中科院分区：
文献类型：
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作者：
Ying Wang;Zhaohui Zuo;Y. Gu;N. Huang;Rong Chen;Buhong Li;H. Qiu;J. Zeng;Jianguo Zhu;
为拓宽光动力学疗法治疗鲜红斑痣（PWS）的可选激光波长，通过数学模拟分析了457 nm激光应用于婴幼儿PWS光动力学疗法的可行性，并通过临床实验进行了验证。对457 nm和532 nm光动力疗法在婴儿PWS模型和成人PWS模型中的单线态氧产率进行了理论模拟。15例PWS患者（14例婴儿和1例成人）40个点分别用457 nm（20个点）和532 nm（20个点）进行两个PDT疗程治疗。模拟结果表明，在相同的功率密度和照射时间下，457 nm PDT和532 nm PDT在婴儿PWS血管中的单线态氧产额相似。然而，在成人PWS血管中，457 nm PDT的单线态氧产率低于532 nm PDT。临床结果显示，457nm PDT和532nm PDT治疗婴儿PWS的疗效无统计学差异。本研究结果表明，457 nm波长激光具有应用于婴儿PWS PDT的潜力。
To expand the optional laser wavelengths of photodynamic therapy (PDT) for port wine stain (PWS), the feasibility of applying a 457 nm laser to the PDT for infantile PWS was analyzed by mathematical simulation and was validated by clinical experiment. Singlet oxygen yield of 457 nm PDT or 532 nm PDT in an infantile PWS model and an adult PWS model was theoretically simulated. Fifteen PWS patients (14 infants and 1 adult) with 40 spots were treated with 457 nm (20 spots) and 532 nm (20 spots), respectively, in two PDT courses. Simulation results showed that under the same power density and irradiation time, singlet oxygen yield of 457 nm PDT and 532 nm PDT are similar in infantile PWS vessels. Yet, in adult PWS vessels, singlet oxygen yield of 457 nm PDT is lower than 532 nm PDT. Clinical outcomes showed that no statistic difference existed between 457 nm PDT and 532 nm PDT for infantile PWS. The result of this study suggested that 457 nm wavelength laser has the potential to be applied in PDT for infantile PWS.