MicroRNA and ovarian cancer.
MicroRNA and ovarian cancer.
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DOI：
10.14670/hh-23.1161
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发表时间：
2008-09
影响因子：
2
通讯作者：
Nikitin AY
中科院分区：
文献类型：
--
作者：
Corney DC;Nikitin AY
卵巢癌仍然是发病率和死亡率的主要原因，过去 30 年生存率几乎没有变化。该疾病的分子生物学研究表明，p53/Rb/p16 肿瘤抑制途径频繁发生突变，并且 c-myc、K-ras 和 Akt 致癌信号传导被激活。最近，miRNA 已被证明在控制增殖、细胞凋亡和癌症状态下改变的许多其他过程中发挥重要作用。在这篇综述中，我们讨论了一些最近发表的文章，这些文章暗示了 microRNA 在卵巢癌中的作用，并评估了这个新领域如何提高我们对该疾病的基本了解并提供改进的诊断和治疗方法。
Ovarian cancer remains a leading cause of morbidity and mortality, with little change in survival rates over the past 30 years. Research in the molecular biology underlying the disease demonstrates frequent mutation in the p53/Rb/p16 tumor suppressor pathways and activation of c-myc, K-ras and Akt oncogenic signaling. Recently, miRNAs have been demonstrated to play an important role in controlling proliferation, apoptosis and many other processes altered in the cancer state. In this review we discuss a number of recent publications that implicate a role for microRNAs in ovarian cancer and assess how this new field may improve our fundamental understanding of the disease and provide improved diagnostic and therapeutic approaches.