Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation
Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation
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DOI：
10.1152/japplphysiol.00057.2016
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发表时间：
2016-06-01
影响因子：
3.3
通讯作者：
Casey, Darren P.
中科院分区：
文献类型：
--
作者：
Hughes, William E.;Ueda, Kenichi;Casey, Darren P.
衰老与收缩诱导的快速血管舒张（ROV）减弱有关。我们试图研究慢性运动训练是否会改善老年人的ROV。此外，我们还研究了年轻人和老年人的心肺健康和ROV之间是否存在关系。长期运动训练的老年人（n = 16； 66 +/- 2岁，平均+/- SE）在前臂和腿部进行不同强度的单一肌肉收缩。用多普勒超声测量肱动脉和股动脉内径及血流速度。血管导度（VC）计算为血流量（ml/min）与平均动脉压（mmHg）之商。这些数据与我们之前发表的来自相同方案的16名未经训练的老年人（66 +/- 1岁，平均+/- SE）和14名年轻成年人（23 +/- 1岁）的研究结果进行了比较。经过训练的老年人在不同腿部运动强度下的峰值（δ VCpeak）和总血管舒张剂（VCtotal）反应高于未经过训练的老年人（P < 0.05）。在任何运动强度下，受过训练的老年人和年轻人在手臂或腿部的反应没有差异（P < 0.05）。在腿部绝对负荷下的一部分受试者的Delta VCpeak比较显示，训练有素的老年人相对于未训练的老年人表现出增强的反应。老年人的运动能力(（V)除以dot（O2峰值））与Delta VCpeak和跨臂VCtotal （r = 0.59 ~ 0.64）和腿部运动强度（r = 0.55 ~ 0.68, P < 0.05）相关。我们的数据表明，1)慢性运动训练改善了训练有素的老年人手臂和腿部的ROV，从而消除了ROV的年龄相关差异；2)老年人四肢的VO(2)峰值与Delta VCpeak反应相关。
Aging is associated with attenuated contraction-induced rapid onset vasodilation (ROV). We sought to examine whether chronic exercise training would improve ROV in older adults. Additionally, we examined whether a relationship between cardiorespiratory fitness and ROV exists in young and older adults. Chronically exercise-trained older adults (n = 16; 66 +/- 2 yr, mean +/- SE) performed single muscle contractions in the forearm and leg at various intensities. Brachial and femoral artery diameter and blood velocity were measured using Doppler ultrasound. Vascular conductance (VC) was calculated as the quotient of blood flow (ml/min) and mean arterial pressure (mmHg). These data were compared with our previously published work from an identical protocol in 16 older untrained (66 +/- 1 yr, mean +/- SE) and 14 young (23 +/- 1 yr) adults. Peak (Delta VCpeak) and total vasodilator (VCtotal) responses were greater in trained compared with untrained older adults across leg exercise intensities (P < 0.05). There were no differences in responses between trained older and young adults in the arm or leg at any exercise intensity (P > 0.05). Comparison of Delta VCpeak in a subset of subjects at an absolute workload in the leg revealed that trained older adults exhibited augmented responses relative to untrained older adults. Exercise capacity ((V) over dot(O2 peak)) was associated with Delta VCpeak and VCtotal across arm (r = 0.59 -0.64) and leg exercise intensities (r = 0.55-0.68, P < 0.05) in older adults. Our data demonstrate that 1) chronic exercise training improves ROV in the arm and leg of trained older adults, such that age-related differences in ROV are abolished, and 2) VO(2)peak is associated with Delta VCpeak responses in both limbs of older adults.