Serum apolipoprotein A2 isoforms in autoimmune pancreatitis
Serum apolipoprotein A2 isoforms in autoimmune pancreatitis
复制标题
DOI：
10.1016/j.bbrc.2018.02.170
复制
发表时间：
2018-03-11
影响因子：
3.1
通讯作者：
Honda, Kazufumi
中科院分区：
文献类型：
--
作者：
Kobayashi, Takashi;Sato, Yu;Honda, Kazufumi
近期，载脂蛋白A2（apoA2）异构体已被报道为胰腺癌的候选血清/血浆生物标志物。然而，自身免疫性胰腺炎（AIP）患者中apoA2异构体的分布尚未得到研究。在本研究中，我们利用酶联免疫吸附测定法评估了AIP患者和健康志愿者（HV）血清中apoA2异构体的分布，即同型二聚体apoA2 - ATQJATQ、异型二聚体apoA2 - ATQJAT以及同型二聚体apoA2 - AT/AT，并对32例AIP患者和38例HV中每种apoA2异构体的临床特征和血清水平进行了研究。AIP患者的apoA2 - ATQJAT计算水平显著低于HV，这与胰腺癌患者的结果一致。有趣的是，大多数AIP患者表现出高水平的apoA2 - ATQ以及低水平的apoA2 - AT，这表明AIP患者中apoA2二聚体的C末端区域加工受到抑制。血清apoA2异构体的这种特定分布可能为AIP患者的疾病状态提供重要信息，并有助于AIP与胰腺癌的鉴别诊断。（C）2018爱思唯尔公司。保留所有权利。
Recently, apolipoprotein A2 (apoA2) isoforms have been reported as candidate serum/plasma biomarkers of pancreatic cancer. However, the distribution of apoA2 isoforms in patients with autoimmune pancreatitis (ALP) has not been investigated yet. In this study, we evaluated the distribution of serum apoA2 isoforms; i.e., homodimer apoA2-ATQJATQ heterodimer apoA2-ATQJAT, and homodimer apoA2-AT/AT, in AIP patients and healthy volunteers (HV) using enzyme-linked immunosorbent assays, and the clinical characteristics and serum levels of each apoA2 isoform in 32 AIP patients and 38 HV were investigated. The calculated apoA2-ATQJAT levels of the AIP patients were significantly lower than those of the HV, which agreed with results obtained for patients with pancreatic cancer. Interestingly, most of the AIP patients exhibited high levels of apoA2-ATQ along with low levels of apoA2-AT, indicating that the processing of the C-terminal regions of apoA2 dimer was inhibited in the AIP patients. This specific distribution of serum apoA2 isoforms might provide important information about the disease states of AIP patients and aid the differential diagnosis of AIP versus pancreatic cancer. (C) 2018 Elsevier Inc. All rights reserved.