Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: a comparison with imipramine.
Kinetic effects of desmethylimipramine treatment on platelet serotonin uptake in depressed patients: a comparison with imipramine.
复制标题
去甲基丙咪嗪治疗对抑郁症患者血小板血清素摄取的动力学影响：与丙咪嗪的比较。
DOI：
10.1016/0165-1781(91)90028-n
复制
发表时间：
1991
影响因子：
11.3
通讯作者：
Moeller,FG
中科院分区：
文献类型：
--
作者：
Rausch,JL;Moeller,FG
The kinetic effects of desmethylimipramine (DMI) on platelet serotonin (5HT) uptake were compared to those of imipramine (IMI) in eight DMI-treated depressed patients and seven IMI-treated depressed patients, and compared to values after patients were off drug for 19 (± 8 SD) and 33 (± 15) days. As expected, IMI was a stronger inhibitor of 5HT uptake than DMI during treatment, with the mean apparentKmin treated patients being elevated nearly threefold over that of the drug-free condition. In DMI-treated patients, the meanKmwas elevated nearly twofold over that of the drug-free condition. Although DMI is considered a preferential norepinephrine uptake inhibitor, the results suggest the following: (1) Significant decreases in the apparent platelet 5HT affinity are achieved with DMI; (2) the inhibition kinetics in depressed patients are competitive; (3) there was a significant relationship betweenKmchange and depression outcome with DMI discontinuation; and (40 DMI, as a metabolite, appears to contribute to the %HT uptake inhibition of IMI in vivo.
