Functional Connectivity Differences of the Subthalamic Nucleus Related to Parkinson's Disease
Functional Connectivity Differences of the Subthalamic Nucleus Related to Parkinson's Disease
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DOI：
10.1002/hbm.23099
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发表时间：
2016-03
影响因子：
4.8
通讯作者：
C. Mathys;J. Caspers;R. Langner;M. Südmeyer;C. Grefkes;K. Reetz;A. Moldovan;J. Michely;J. Heller;C. Eickhoff;B. Turowski;A. Schnitzler;F. Hoffstaedter;S. Eickhoff
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文献类型：
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作者：
C. Mathys;J. Caspers;R. Langner;M. Südmeyer;C. Grefkes;K. Reetz;A. Moldovan;J. Michely;J. Heller;C. Eickhoff;B. Turowski;A. Schnitzler;F. Hoffstaedter;S. Eickhoff
帕金森病（PD）的一个典型特征是丘脑下核（STN）的病理活动。在这里，我们测试了多巴胺能治疗的PD患者的STN功能连通性是否与健康对照组（HC）不同，以及某些脑区域的STN功能连通性与运动症状之间是否存在（反）相关性。我们使用功能性磁共振成像研究了54例PD患者和55例HC患者在年龄、性别和扫描仪运动范围内匹配的全脑静息状态与STN的功能连接。与HC相比，我们发现PD患者右小脑I脚和右腹内侧前额叶区STN -负偶联减弱。此外，我们观察到与HC相比，双侧顶叶内沟/顶叶上皮层、右侧感觉运动皮层、右侧前运动皮层和左侧视觉皮层的负STN偶联增强。最后，我们发现与运动症状严重程度相关的左脑岛的STN阳性偶联性下降，以及与PD相关运动症状进展相关的左右脑岛间功能连通性下降。运动症状相关的脑岛（突出网络和执行功能的关键区域）与STN的分离可能与PD中众所周知的执行功能障碍有关。此外，脑岛和STN之间的解耦也可能导致区分相关和不相关显著环境刺激的阈值设置不足，这解释了PD中干扰反应控制的观察结果。总之，PD患者的运动症状与STN与执行功能关键区域之间耦合减少有关。中国生物医学工程学报（英文版），2016。©2015 Wiley期刊公司
A typical feature of Parkinson's disease (PD) is pathological activity in the subthalamic nucleus (STN). Here, we tested whether in patients with PD under dopaminergic treatment functional connectivity of the STN differs from healthy controls (HC) and whether some brain regions show (anti‐) correlations between functional connectivity with STN and motor symptoms. We used functional magnetic resonance imaging to investigate whole‐brain resting‐state functional connectivity with STN in 54 patients with PD and 55 HC matched for age, gender, and within‐scanner motion. Compared to HC, we found attenuated negative STN‐coupling with Crus I of the right cerebellum and with right ventromedial prefrontal regions in patients with PD. Furthermore, we observed enhanced negative STN‐coupling with bilateral intraparietal sulcus/superior parietal cortex, right sensorimotor, right premotor, and left visual cortex compared to HC. Finally, we found a decline in positive STN‐coupling with the left insula related to severity of motor symptoms and a decline of inter‐hemispheric functional connectivity between left and right STN with progression of PD‐related motor symptoms. Motor symptom related uncoupling of the insula, a key region in the saliency network and for executive function, from the STN might be associated with well‐known executive dysfunction in PD. Moreover, uncoupling between insula and STN might also induce an insufficient setting of thresholds for the discrimination between relevant and irrelevant salient environmental stimuli, explaining observations of disturbed response control in PD. In sum, motor symptoms in PD are associated with a reduced coupling between STN and a key region for executive function. Hum Brain Mapp 37:1235–1253, 2016. © 2015 Wiley Periodicals, Inc.