TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
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DOI：
10.1038/ni1185
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发表时间：
2005-05-01
影响因子：
30.5
通讯作者：
Kuchroo, VK
中科院分区：
文献类型：
--
作者：
Meyers, JH;Chakravarti, S;Kuchroo, VK
新鉴定的TIM蛋白家族与辅助性T细胞1型（T（H）1）和T（H）2免疫应答的调节相关。TIM-1与哮喘有遗传联系，是甲型肝炎病毒的受体，但TIM-1的内源性配体尚不清楚。在这里，我们表明，TIM-4，这是由抗原呈递细胞表达，是TIM-1的配体。在体内施用可溶性TIM-1-免疫球蛋白（TIM-1-IG）融合蛋白或TIM-4-IG融合蛋白导致T细胞过度增殖，并且TIM-4-IG在体外共刺激由CD 3和CD 28介导的T细胞增殖。这些数据表明TIM-1-TIM-4相互作用参与调节T细胞增殖。
The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1-Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation.