Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study
Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study
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DOI：
10.1016/j.ijcard.2018.05.075
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发表时间：
2018-09-15
影响因子：
3.5
通讯作者：
Ueshima, Hirotsugu
中科院分区：
文献类型：
--
作者：
Hisamatsu, Takashi;Miura, Katsuyuki;Ueshima, Hirotsugu
背景：运动降低冠心病风险的机制仍然知之甚少。鸢尾素是一种运动诱导的骨骼肌分泌的多肽，被认为可能介导运动的有益作用，特别是在代谢调节和动脉粥样硬化的发展中。我们研究了是否较高的血清鸢尾素水平与冠状动脉粥样硬化的发病率和进展较低。方法和结果：我们进行了一项前瞻性的，以人口为基础的研究，年龄在40-79岁的日本男性没有已知的冠心病。我们使用酶联免疫吸附试验测量基线血清苦参素水平，并通过连续计算机断层扫描定量冠状动脉钙化（CAC）。在基线时的1038名参与者（平均年龄63.9岁）中，670名（64.6%）患有普遍的CAC。在随访的810名参与者中（中位数，5.1年），407名（50.3%）经历了CAC进展。在Poisson回归中，校正了年龄和行为因素的稳健误差方差，血清鸢尾素水平与CAC患病率呈负相关（第四与第一四分位数的相对风险[RR][95%置信区间]，0.88 [0.78-0.99];趋势P = 0.016）和CAC进展（RR，0.76 [0.63-0.91];趋势P= 0.002）。在进一步校正心脏代谢危险因素后，与CAC患病率的负相关性消失（RR，0.95 [0.84-1.08];趋势P= 0.319），但与CAC进展的负相关性持续存在（RR，0.77 [0.64-0.93];趋势P = 0.003）。这些协会是一致的，当我们应用有序logistic回归和跨亚组的心脏代谢危险因素status.Conclusions：较高的血清鸢尾素水平与冠状动脉粥样硬化的负担较轻。这种关联将通过和超越传统的心脏代谢途径介导。(c)2018 Elsevier B. V.版权所有。
Background: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis.Methods and results: We performed a prospective, population-based study of Japanese men aged 40-79 years without known coronary heart disease. We measured baseline serumirisin levels using an enzyme-linked immunosorbent assay and quantified coronary artery calcification (CAC) from serial computed tomography scans. Of 1038 participants (mean age, 63.9 years) at baseline, 670 (64.6%) had prevalent CAC. Of 810 participants at follow-up (median, 5.1 years), 407 (50.3%) experienced CAC progression. In Poisson regression with robust error variance adjusted for age and behavioral factors, serum irisin levels were inversely associated with CAC prevalence (relative risk [RR] of 4th versus 1st quartiles [95% confidence interval], 0.88 [0.78-0.99]; trend P = 0.016) and CAC progression (RR, 0.76 [0.63-0.91]; trend P= 0.002). After further adjustment for cardiometabolic risk factors, the inverse association with CAC prevalence disappeared (RR, 0.95 [0.84-1.08]; trend P= 0.319), but that with CAC progression persisted (RR, 0.77 [0.64-0.93]; trend P = 0.003). These associations were consistent when we applied ordinal logistic regression and across subgroups by cardiometabolic risk factor status.Conclusions: Higher serum irisin levels were associated with less burden of coronary atherosclerosis. This association would be mediated through and beyond traditional cardiometabolic pathways. (c) 2018 Elsevier B.V. All rights reserved.