Arterial stiffness and the development of hypertension - The ARIC study
Arterial stiffness and the development of hypertension - The ARIC study
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DOI：
10.1161/01.hyp.34.2.201
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发表时间：
1999-08-01
期刊：
影响因子：
8.3
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Liao, DP;Arnett, DK;Heiss, G
大中型动脉弹性降低被认为与心血管疾病有关。我们前瞻性地研究了6,992名血压正常的男性和女性的动脉弹性与高血压的发展之间的关系，这些男性和女性的年龄在45岁到之间，基线来自基于人群的双指标动脉粥样硬化风险研究。通过高分辨率B型超声检查左颈总动脉测量动脉弹性，调整后的动脉内径变化(以微米为单位，同时调整舒张压、脉压、脉压平方、舒张期动脉直径和高度)、彼得森弹性模数(千帕斯卡)、杨氏弹性模数(千帕斯卡)和贝塔僵硬指数。高血压(n=551)的定义为：收缩压大于或等于160 mm Hg，舒张压大于或等于95 mm Hg，或在每3年进行一次随访检查时使用降压药。在随访期间发生高血压的患者中，年龄、种族、中心、性别、教育程度、吸烟、心率和肥胖调整后的动脉内径变化、Peterson弹性模数、杨氏弹性模数和β僵硬指数的调整平均值(SE)分别为397(5)、148(2.0)、787(12.7)和11.43(0.16)，相比之下，分别为407(1)、124(0.6)、681(3.7)和10.34(0.05)，对于那些没有这样做的人。以调整后的动脉内径变化来衡量，调整后的高血压累积发生率从动脉弹性最高的四分位数到最低的四分位数分别为6.7%、8.0%、7.3%和9.6%(P
Decreased elasticity in large and medium-sized arteries has been postulated to be associated with cardiovascular diseases. We prospectively examined the relation between arterial elasticity and the development of hypertension over 6 years of follow-up in a cohort of 6992 normotensive men and women aged 45 to 64 years at baseline from the biracial, population-based Atherosclerosis Risk in Communities (ARIC) Study. Arterial elasticity was measured from high-resolution B-mode ultrasound examination of the left common carotid artery as adjusted arterial diameter change (in micrometers, simultaneously adjusted for diastolic blood pressure, pulse pressure, pulse pressure squared, diastolic arterial diameter, and height), Peterson's elastic modulus (in kilopascals), Young's elastic modulus (in kilopascals), and beta stiffness index. Incident hypertension (n=551) was defined as systolic blood pressure greater than or equal to 160 mm Hg, diastolic blood pressure greater than or equal to 95 mm Hg, or the use of antihypertensive medication at a follow-up examination conducted every 3 years. The age-, ethnicity-, center-, gender-, education-, smoking-, heart rate-, and obesity-adjusted means (SE) of baseline adjusted arterial diameter change, Peterson's elastic modulus, Young's elastic modulus, and beta stiffness index were 397 (5), 148 (2.0), 787 (12.7), and 11.43 (0.16), respectively, in persons who developed hypertension during follow-up, in contrast to 407 (1), 124 (0.6), 681 (3.7), and 10.34 (0.05), respectively, for persons who did not. The similarly adjusted cumulative incident rates of hypertension from the highest to the lowest quartiles of arterial elasticity were 6.7%, 8.0%, 7.3%, and 9.6%, respectively, when measured by adjusted arterial diameter change (P