Complementation and Epistasis in Viral Coinfection Dynamics
Complementation and Epistasis in Viral Coinfection Dynamics
复制标题
病毒共感染动力学中的互补和上位性
DOI：
10.1534/genetics.108.099796
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发表时间：
2009-05-01
期刊：
影响因子：
3.3
通讯作者：
Feldman, Marcus W.
中科院分区：
文献类型：
--
作者：
Gao, Hong;Feldman, Marcus W.
RNA病毒群体的共感染导致两种重要现象：互补和重组。在这两者中，互补对对抗有害突变的选择有很强的影响，这在早期的研究中已经得到证实。由于互补延迟了不适合突变的清除，共同感染可能对病毒种群的进化有害。本文采用确定性模型和随机模拟来探讨互补与其他进化因素（即突变、选择和上位性）之间相互作用的机制。我们发现，强互补性略微降低了病毒种群的整体适应度，但大大增强了其多样性和稳健性，特别是在与选择和上位性相互作用时。
Coinfection in RNA virus populations results in two important phenomena, complementation and recombination. Of the two, complementation has a strong effect on selection against deleterious mutations, as has been confirmed in earlier studies. As complementation delays the purging of less-fit mutations, coinfection may be detrimental to the evolution of a virus population. Here we employ both deterministic modeling and stochastic simulation to explore the mechanisms underlying the interactions between complementation and other evolutionary factors, namely, mutation, selection, and epistasis. We find that strong complementation reduces slightly the overall fitness of a virus population but substantially enhances its diversity and robustness, especially when interacting with selection and epistasis.