Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.
Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.
复制标题
载脂蛋白 E 在调节神经突生长中的作用：细胞内载脂蛋白 E 的潜在作用。
DOI：
10.1042/bst0260257
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发表时间：
1998
影响因子：
3.9
通讯作者：
Mahley,RW
中科院分区：
文献类型：
--
作者：
Pitas,RE;Ji,ZS;Weisgraber,KH;Mahley,RW
Apolipoprotein (apo) E was first discovered more than 25 years ago [1, 2] and plays a central role in the transport of lipids in the plasma and in the maintenance of cholesterol homeostasis [3]. ApoE also plays important roles in normal metabolism and functioning of the central nervous system and in neuropathology [3]. This 299 amino acid, 34 kDa protein occurs in three common isoforms, which are products of three alleles at the same gene locus [4]. The products of these alleles, apoE2, apoE3, and apoE4, differ at two positions, amino acids 112 and 158: apoE3 has cysteine at position 112 and arginine at position 158, whereas apoE2 has cysteine at both positions and apoE4 has arginine at both positions [3, 5]. The amino acid substitutions in the apoE isoforms have an impact upon plasma cholesterol levels, their lipoprotein receptor interactions, and their associations with Alzheimer’s disease [3, 5, 6]. The apoE2 allele appears to be associated with a decreased risk and the apoE4 allele is associated with an increased risk [6] of developing Alzheimer’s disease [7], as compared to apoE3. The apoE4 allele is over-represented in patients with late onset familial and sporadic Alz-
