INDUCTION OF MAMMARY FIBROADENOMAS IN RATS BY ADENOVIRUS TYPE 9
INDUCTION OF MAMMARY FIBROADENOMAS IN RATS BY ADENOVIRUS TYPE 9
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DOI：
10.1002/ijc.2910130303
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发表时间：
1974-01-01
影响因子：
6.4
通讯作者：
SJOGREN, HO
中科院分区：
文献类型：
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作者：
ANKERST, J;JONSSON, N;SJOGREN, HO
将9型腺病毒接种到新生Wistar/Furth大鼠中后，7/7只雌性大鼠在病毒接种后14-25周内发生了一个或多个乳腺纤维腺瘤。在接种相同病毒的雄性大鼠或未处理的对照组中未观察到肿瘤。新生儿接种腺病毒5型，在相同的HeLa细胞产生的，在两种性别的阴性结果。结果表明，良性乳腺肿瘤可以诱导大鼠的病毒和乳腺纤维腺瘤是由腺病毒9型，以前已知的是能够转化细胞体外，但不能诱导肿瘤在体内。
After inoculation of adenovirus type 9 into newborn Wistar/Furth rats, seven out of seven females developed one or several mammary fibroadenomas within 14–25 weeks after virus inoculation. No tumours were observed in male rats inoculated with the same virus or in untreated controls. Neonatal inoculations of adenovirus type 5, produced on the same HeLa cells, gave negative results in both sexes. The results indicate that benign mammary tumours can be induced in rats by a virus and that mammary fibroadenomas are induced by adenovirus type 9, previously known to be capable of transforming cellsin vitrobut not of inducing tumoursin vivo.