The Inverse Relationship Between Endothelium-Dependent Vasodilation and Blood Pressure is Lost After Cardiopulmonary Bypass.
The Inverse Relationship Between Endothelium-Dependent Vasodilation and Blood Pressure is Lost After Cardiopulmonary Bypass.
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DOI：
10.1007/s12265-021-10124-w
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发表时间：
2021-12
影响因子：
3.4
通讯作者：
Lamb FS
中科院分区：
文献类型：
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作者：
Stark RJ;Krispinsky LT;Lamb FS
体外循环（CPB）是手术矫正先天性心脏缺陷所必需的，它会引起急性炎症反应，损害术后内皮功能。因此，我们假设cpb介导的炎症会破坏术前内皮功能和血压之间的关系。通过激光多普勒灌注监测和离子电泳，我们发现虽然内皮依赖性血管对乙酰胆碱（ACh）刺激的反应性与收缩压（SBP）之间存在显著的负相关，但CPB后这种关系消失了。使用硝普钠（SNP）的内皮非依赖性血管反应性与收缩压之间没有关系，无论是在cpb前还是之后的任何时间点。此外，CPB时间和炎症因子均与乙酰胆碱反应程度无关。这些数据表明CPB后内皮损伤的测量可能比单独收缩压更能反映心血管健康状况。
Cardiopulmonary bypass (CPB) is required for the surgical correction of congenital heart defects and incites an acute inflammatory response that impairs endothelial function post-operatively. Therefore, we hypothesized that the pre-operative relationship between endothelial function and blood pressure would be impaired after CPB-mediated inflammation. Using laser Doppler perfusion monitoring coupled with iontophoresis, we found that while there was a significant inverse correlation between endothelium-dependent vascular reactivity to acetylcholine (ACh) stimulation and systolic blood pressure (SBP), this relationship was lost after CPB. No relationship was observed between endothelium-independent vascular reactivity using sodium nitroprusside (SNP) and SBP either pre-CPB or any point thereafter. Additionally, neither CPB time nor inflammatory cytokines correlated with the degree of responsiveness to ACh. These data suggest that the measurement of endothelium impairment after CPB may be more reflective of cardiovascular health than SBP alone.
DOI：
10.1097/pcc.0000000000002049
发表时间：
2020-01
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
--
作者：
Krispinsky LT;Stark RJ;Parra DA;Luan L;Bichell DP;Pietsch JB;Lamb FS
通讯作者：
Lamb FS
影响因子：
4.6
作者：
EVORA, PRB;PEARSON, PJ;SCHAFF, HV
通讯作者：
SCHAFF, HV
影响因子：
158.5
作者：
PANZA, JA;QUYYUMI, AA;EPSTEIN, SE
通讯作者：
EPSTEIN, SE