Gene transfers, like fossils, can date the Tree of Life
Gene transfers, like fossils, can date the Tree of Life
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DOI：
10.1101/193813
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发表时间：
2017-09
期刊：
影响因子：
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通讯作者：
Adrián A. Davín;Éric Tannier;T. Williams;B. Boussau;V. Daubin;G. Szöllősi
中科院分区：
文献类型：
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作者：
Adrián A. Davín;Éric Tannier;T. Williams;B. Boussau;V. Daubin;G. Szöllősi
生物多样性一直以微生物为主，细菌、古菌和微生物真核生物化石的稀缺阻碍了对生命树的全面测年。在这里，我们展示了从现代基因组分析中推导出的横向基因转移模式，编码了关于整个生命历史中谱系的时间共存的新的和丰富的信息来源。我们使用新的系统发育学方法重建了数千个基因家族的历史，并证明了基因转移所暗示的日期与细菌、古生物和真核生物中松弛的分子时钟的估计一致。对转移和时钟之间的差异以及与哺乳动物化石的比较表明，微生物中的基因转移对确定生命树的年代具有潜在的信息，就像大型生物的地质记录一样。
Biodiversity has always been predominantly microbial and the scarcity of fossils from bacteria, archaea and microbial eukaryotes has prevented a comprehensive dating of the tree of life. Here we show that patterns of lateral gene transfer deduced from the analysis of modern genomes encode a novel and abundant source of information about the temporal coexistence of lineages throughout the history of life. We use new phylogenetic methods to reconstruct the history of thousands of gene families and demonstrate that dates implied by gene transfers are consistent with estimates from relaxed molecular clocks in Bacteria, Archaea and Eukaryotes. An inspection of discrepancies between transfers and clocks and a comparison with mammal fossils show that gene transfer in microbes is potentially as informative for dating the tree of life as the geological record in macroorganisms.