Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity
Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity
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DOI：
10.1007/s00403-002-0371-6
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发表时间：
2003-04-01
影响因子：
3
通讯作者：
Harada, S
中科院分区：
文献类型：
--
作者：
Umezawa, Y;Ozawa, A;Harada, S
泛发性脓疱性银屑病是一种罕见的皮肤病。因此，很少有超过10例GPP患者在同一机构接受治疗的报告。这种疾病的严重程度及其对每种治疗方式的反应在患者中各不相同。在某些情况下，GPP会危及生命。但在另一些情况下，它可能表现为长期的良性慢性过程。在开始治疗之前，需要了解用于治疗GPP的每种药物的疗效和副作用。在我们的多中心研究中，我们比较了几种全身给药药物的有效性和不良反应。根据对临床症状和实验室检查结果的评分，对疾病严重程度进行了独特的分类，我们在此提出了治疗GPP的治疗指南。
Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten patients with GPP who were treated at the same institution. The severity of this disease and its response to each therapeutic modality vary among patients. In some GPP is life-threatening. but in others it may show a benign, chronic course for a long period of time. Before starting treatment a knowledge of the therapeutic efficacy and side effects of each drug used in the treatment of GPP is necessary. In our multicenter study, we compared the effectiveness of and adverse reactions to several systemically administered drugs. Following the development of a unique classification of the disease severity based on scoring the clinical symptoms and the laboratory findings, we propose here therapeutic guidelines for the treatment of GPP.