Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia.
Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia.
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DOI：
10.1093/cercor/bhs422
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发表时间：
2014-05
期刊：
影响因子：
3.7
通讯作者：
P. Savadjiev;T. Whitford;M. Hough;C. C. V. Hohenberg-C.;S. Bouix;C. Westin;M. Shenton;Timothy J. Crow;Anthony James;M. Kubicki
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文献类型：
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作者：
P. Savadjiev;T. Whitford;M. Hough;C. C. V. Hohenberg-C.;S. Bouix;C. Westin;M. Shenton;Timothy J. Crow;Anthony James;M. Kubicki
正常人脑的特点是大体解剖不对称。这种被称为“扭矩”的模式与性别二型性有关：男性的大脑往往比女性的大脑更不对称。这一事实，以及众所周知的大脑发育(女性更快)和精神病(男性更早，结果更差)的性别差异，导致了一种理论，即精神分裂症是一种障碍，在大脑扭矩的发展中，性别相关的异常，语言能力的相关，导致大脑之间连接的变化，这与精神病有因果关系(Crow TJ，Paez P，Chance SE)。2007年。精神障碍中的膝盖骨错位与性别差异。国际牧师精神病学。19(4)：449-457。为了支持这一理论，我们分析了青春期精神分裂症患者大脑半球间白质连接的几何结构，尤其是性别，使用了最近引入的扩散张量成像数据中白质几何计算的框架(Savadjiev P，Kindlmann GL，Bouix S，Shenton ME，Wstin CF)。2010年。来自扩散张量梯度的局部白色几何图形。神经影像。49(4)：3175-3186。我们的结果揭示了一种性别相关的白质几何异常模式，符合Crow扭矩理论的预测，并与患者症状的严重程度相关。据我们所知，这是第一次将白质连接性的几何差异与精神分裂症的扭矩联系起来的研究。
The normal human brain is characterized by a pattern of gross anatomical asymmetry. This pattern, known as the "torque", is associated with a sexual dimorphism: The male brain tends to be more asymmetric than that of the female. This fact, along with well-known sex differences in brain development (faster in females) and onset of psychosis (earlier with worse outcome in males), has led to the theory that schizophrenia is a disorder in which sex-dependent abnormalities in the development of brain torque, the correlate of the capacity for language, cause alterations in interhemispheric connectivity, which are causally related to psychosis (Crow TJ, Paez P, Chance SE. 2007. Callosal misconnectivity and the sex difference in psychosis. Int Rev Psychiatry. 19(4):449-457.). To provide evidence toward this theory, we analyze the geometry of interhemispheric white matter connections in adolescent-onset schizophrenia, with a particular focus on sex, using a recently introduced framework for white matter geometry computation in diffusion tensor imaging data (Savadjiev P, Kindlmann GL, Bouix S, Shenton ME, Westin CF. 2010. Local white geometry from diffusion tensor gradients. Neuroimage. 49(4):3175-3186.). Our results reveal a pattern of sex-dependent white matter geometry abnormalities that conform to the predictions of Crow's torque theory and correlate with the severity of patients' symptoms. To the best of our knowledge, this is the first study to associate geometrical differences in white matter connectivity with torque in schizophrenia.