Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management.
Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management.
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DOI：
10.1513/pats.200807-074th
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发表时间：
2008-12-01
期刊：
影响因子：
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通讯作者：
Spira, Avrum
中科院分区：
文献类型：
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作者：
Zeskind, Julie E;Lenburg, Marc E;Spira, Avrum
虽然香烟烟雾在慢性阻塞性肺疾病（COPD）中的作用是无可争议的，但吸入烟雾导致疾病发病机制的分子机制仍不清楚。有效诊断和管理COPD方法的主要障碍之一是患有该疾病的患者表现出的显著异质性。对COPD患者气道和肺组织的全基因组基因表达研究提供了深入了解疾病发病机制的机会，既可以从分子上了解导致这种异质性的致病过程，又可以针对这些过程进行靶向治疗。这篇综述的重点是综合和整合有限数量的高通量基因表达研究，已进行肺组织和气道样本吸烟者与COPD。使用计算方法比较几项肺组织研究，我们发现结果表明了基本的相似性，并确定了COPD潜在的共同生物学过程，尽管每项研究都确定了基本上不重叠的差异表达基因列表。鉴于这些相似性，我们认为，额外的肺组织和气道基因表达研究是必要的，并提出了一个路线图，这些研究如何可能导致临床相关的工具，将影响COPD的管理。
While the role cigarette smoke plays in chronic obstructive pulmonary disease (COPD) is undisputed, the molecular mechanisms by which inhaled smoke contributes to disease pathogenesis remains unclear. One of the major barriers to effective approaches to diagnose and manage COPD is the remarkable heterogeneity displayed by patients with the disease. Whole-genome gene-expression studies of airway and lung tissue from patients with COPD provide an opportunity to gain insights into disease pathogenesis, allowing for both a molecular understanding of the pathogenic processes that contribute to this heterogeneity, and the ability to target therapies to these processes. This review focuses on synthesizing and integrating the limited numbers of high-throughput gene expression studies that have been conducted on lung tissue and airway samples from smokers with COPD. Comparing several lung tissue studies using computational approaches, we find that the results suggest fundamental similarities and identify common biological processes underlying COPD, despite each study having identified largely nonoverlapping lists of differentially expressed genes. Given these similarities, we argue that additional lung tissue and airway gene-expression studies are warranted, and present a roadmap for how such studies could lead to clinically relevant tools that would impact COPD management.