Risk factors and molecular characterization of acute sporadic symptomatic hepatitis E virus infection in Thailand
Risk factors and molecular characterization of acute sporadic symptomatic hepatitis E virus infection in Thailand
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DOI：
10.1016/s1995-7645(14)60121-8
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发表时间：
2014-09-01
影响因子：
3.1
通讯作者：
Poovorawan, Yong
中科院分区：
文献类型：
--
作者：
Poovorawan, Kittiyod;Jitmitrapab, Salyavit;Poovorawan, Yong
Objective: To report clinical outcomes and viral genotypes of acute symptomatic hepatitis E virus (HEY) infection in Thailand. Methods: Forty patients with acute symptomatic HEY infection were recruited during 2009-2013. Clinical, demographic and laboratory data were collected. Diagnosis was accomplished by detection of anti-HEY IgM and/or HEY RNA in the serum or stool. HEY genotypes were classified by direct sequencing of RT-PCR products and phylogenetic analysis. Results: The high risk group, comprising immune-compromised, liver cirrhosis and very elderly (>80 years) patients (17 cases), had higher levels of serum alkaline phosphatase at presentation compared with the low risk group. Two fatal cases resulted from acute hepatitis E in the high risk group. Initial clinical presentation did not show statistically significant differences. In six cases (6/40), the virus could tic detected in scrum or stool by RT-PCR and sequencing. Upon molecular characterization, the viruses were classified as HEV genotype 3f and were in the same cluster as Thai swine REV. Conclusions: Our data showed that acute HEY infection has various clinical presentations and outcomes. Higher levels of serum alkaline phosphatase were observed in high risk patients. All isolated viruses were identified as HEY genotype 3f possibly originating from swine.
