Clinical Trials of Adult Stem Cell Therapy in Patients with Ischemic Stroke.
Clinical Trials of Adult Stem Cell Therapy in Patients with Ischemic Stroke.
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DOI：
10.3988/jcn.2016.12.1.14
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Bang OY
中科院分区：
文献类型：
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作者：
Bang OY
干细胞疗法被认为是神经缺陷患者潜在的再生策略。涉及缺血性中风动物模型的研究表明，移植到大脑中的干细胞可以改善功能。随着目前对引入干细胞的作用及其作用机制的认识取得进展，自 2005 年以来，已经在中风患者中进行了多项干细胞治疗临床试验，包括使用间充质干细胞、骨髓单核细胞和神经干/祖细胞的研究。此外，多项利用成体干细胞治疗缺血性中风的临床试验正在进行中。这篇综述介绍了我们对成体干细胞的了解现状和临床试验结果，并介绍了正在进行的成体干细胞治疗中风领域的临床研究。
Stem cell therapy is considered a potential regenerative strategy for patients with neurologic deficits. Studies involving animal models of ischemic stroke have shown that stem cells transplanted into the brain can lead to functional improvement. With current advances in the understanding regarding the effects of introducing stem cells and their mechanisms of action, several clinical trials of stem cell therapy have been conducted in patients with stroke since 2005, including studies using mesenchymal stem cells, bone marrow mononuclear cells, and neural stem/progenitor cells. In addition, several clinical trials of the use of adult stem cells to treat ischemic stroke are ongoing. This review presents the status of our understanding of adult stem cells and results from clinical trials, and introduces ongoing clinical studies of adult stem cell therapy in the field of stroke.